T cell exhaustion and senescence for ovarian cancer immunotherapy

Zhao, Jiao; Wang, Zhongmiao; Tian, Yingying; Ning, Jing; Ye, Huinan

doi:10.1016/j.semcancer.2024.07.001

Seminars in Cancer Biology

2024

DOI: 10.1016/j.semcancer.2024.07.001

|View full text |Cite

T cell exhaustion and senescence for ovarian cancer immunotherapy

Jiao Zhao,

Zhongmiao Wang,

Yingying Tian

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 180 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer

Gu,

Liu,

Zheng

et al. 2024

Seminars in Cancer Biology

View full text Add to dashboard Cite

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer

Gu,

Liu,

Zheng

et al. 2024

Seminars in Cancer Biology

View full text Add to dashboard Cite

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

He,

Qiu,

Yang

et al. 2025

Seminars in Cancer Biology

View full text Add to dashboard Cite

CD8+ T cell exhaustion in the tumor microenvironment of breast cancer

Xie,

Xi,

Lei

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

CD8+ T cells are crucial cytotoxic components of the tumor immune system. In chronic inflammation, they become low-responsive, a state known as T cell exhaustion (TEX). The aim of immune checkpoint blockade is to counteract TEX, yet its dynamics in breast cancer remain poorly understood. This review defines CD8+ TEX and outlines its features and underlying mechanisms. It also discusses the primary mechanisms of CD8+ TEX in breast cancer, covering inhibitory receptors, immunosuppressive cells, cytokines, transcriptomic and epigenetic alterations, metabolic reprogramming, and exosome pathways, offering insights into potential immunotherapy strategies for breast cancer.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

T cell exhaustion and senescence for ovarian cancer immunotherapy

Cited by 4 publications

References 180 publications

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

CD8+ T cell exhaustion in the tumor microenvironment of breast cancer

Contact Info

Product

Resources

About