T-cell/histiocyte-rich large B-cell lymphoma in a child: A case report and review of literature

Abstract

T-cell/histiocyte-rich large B-cell lymphoma is uncommon in children population. There were few cases reported in the literature with wide range clinical presentations including advanced stage, and more involvement of liver, spleen and bone marrow. Head and neck lymphadenopathy tends to present in younger children. We report a case of 10-year-old boy who initially presented intermittent fever, headaches and neck lymphadenopathy. Subsequently, he developed diffuse lymphadenopathy and hepatosplenomegaly. T-cell/histiocyte-rich large B-cell lymphoma was diagnosed on a cervical lymph node biopsy. Cervical lymphadenopathy in this age group is most commonly reactive or non-malignant processes. Lymphoma is much less frequent; mainly are non-Hodgkin lymphomas. However, a subset of large B-cell lymphoma called T-cell/histiocyte- rich B-cell lymphoma is rare in children.

T-cell/Histiocyte-rich Large B-cell Lymphoma in an Adolescent from Abidjan-Ivory Coast: Case Report

“…Immunohistochemistry is very important for the diagnosis of THRLBCL. Indeed, at a lower examination, classical Hodgkin's lymphoma, which is more frequent in the pediatric population, can mimic THRLBCL as it shares histological similarities (Wei et al, 2018). This poses a real problem of differential diagnosis and can lead to an under or misdiagnosis of THRLBCL in this population, especially in our case where the clinical presentation was atypical.…”

T-cell/Histiocyte-rich Large B-cell Lmphoma in Pediatric Patients: a Reported Case of a 16-year-old Patient in Clinical Haematology Department of the University Teaching Hospital of Yopougon (Abidjan-Ivory Coast)

“…Immunohistochemistry is very important for the diagnosis of THRLBCL. Indeed, at lower examination, classical Hodgkin's lymphoma, which is more frequent in the pediatric population, can mimic THRLBCL as it shares histological similarities (Wei et al, 2018). This poses a real problem of differential diagnosis and can lead to an under or misdiagnosis of THRLBCL in this population, especially in our case where the clinical presentation was atypical.…”

Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene

“…Sato et al described THRLBCL in multiple lymph nodes with bone metastases, which is exceedingly rare in children and AT patients. The abovementioned AT pediatric patient did not respond to the treatment (R-CHOP chemotherapy) and, before pre-transplant treatment, died of cardiac insufficiency and multiple organ failure induced by the rapid progression of the disease [ 26 , 27 , 28 ].…”