T Cell Immune Function in Newborn Infants

Semenzato, G.; Piovesan, A; Amadori, G; Colombatti, Marco; Gasparotto, G; Rubaltelli, Firmino F.

doi:10.1159/000241250

Cited by 5 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of T-lymphocytc subsets suggested that sup pressor T cells in cord blood differ phenotypically from their adult counterpart: these cells lack Fc receptors [14] and seem to origi nate from a T4+ population, while T8+ cells in cord blood present poor suppressor activ ity [26]. Semenzato et al [19] observed an increase in the percentage and absolute num ber of lymphocytes that are able to form rosettes with sheep erythrocytes when incu bated at 37 °C for 60 min at low (8:1) erythrocyte/lymphocyte ratio ('active' E rosettes). As high proportions of lymphocytes forming 'active' E rosettes have been found in fetal thymus [25], it is likely that 'active' E rosette may represent a marker of immature T lym phocytes [5].…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Immaturity of T and B Lymphocytes in Cord Blood of Full-Term Normal Neonates

et al. 1983

View full text Add to dashboard Cite

We examined mononuclear cell subsets in cord blood of normal newborns by surface marker analysis. The percentages of T lymphocytes (E-rosetting and T3⁺ cells) were lower in cord blood than in peripheral blood (PB) from adults, while the percentage and absolute number of T6⁺ cells were higher in cord blood. As the sum of T4⁺ and T8⁺ cells exceeded the values of E-rosetting lymphocytes in cord blood, we suggest that immature lymphocytes with the phenotype of ‘common’ thymocytes (T6⁺, T4⁺, T8⁺) are present in cord blood of full-term newborns. Higher percentage and absolute number of B lymphocytes were detected in cord blood. More than 50% of B cells in cord blood formed rosettes with mouse erythrocytes, a surface marker of functional immaturity. Finally, cells bearing receptors for IgG-Fc fragments or C3 and expressing Ia-like and Ml antigens were uniformly increased in cord blood, suggesting higher percentages of cells of the monocytic lineage.

show abstract

Section: Discussionmentioning

confidence: 99%

Phenotypic Immaturity of T and B Lymphocytes in Cord Blood of Full-Term Normal Neonates

et al. 1983

View full text Add to dashboard Cite

show abstract

“…At the time of human birth, the proportion of lymphocytes represented by T-cells is lowest and increases over time (Semenzato et al, 1980;Series et al, 1991;Berry et al, 1992;Erkellar-Yuksel et al, 1992;Hannet et al, 1992;Plebani et al, 1993;Hulstaert et al, 1994). Specifically, absolute numbers of both CD4 þ and CD8 þ subsets increase, whereas the CD4/CD8 ratio has been variably reported to differ, or not, with time after birth (Foa et al, 1984;Hannet et al, 1992;Plebani et al, 1993).…”

Section: Postnatal Development Of the Immune Systemmentioning

confidence: 99%

Species comparison of anatomical and functional immune system development

Holsapple

West

Landreth

2003

Birth Defects Research Pt B

238

157

View full text Add to dashboard Cite

The components of the immune system have not been traditionally emphasized as potential target organs in standard developmental and reproductive toxicity (DART) protocols. A number of workshops have been organized in recent years to examine scientific questions that underlie developmental immunotoxicity tests, and the interpretation of results as they relate to human risk assessment. A key question that must be addressed is to determine the most appropriate species and strains to model the developing human immune system. The objective of this review is to compare the anatomical and functional development of the immune system in several species important to either preclinical studies for drug development or safety assessments for chemicals, with what is known in humans. The development of the immune system in humans will be compared to what is known in mice, rats, dogs and nonhuman primates.

show abstract