T-cell involvement in osteoclast biology: implications for rheumatoid bone erosion

O’Gradaigh, Donncha; Compston, Juliet

doi:10.1093/rheumatology/keg447

Cited by 30 publications

(22 citation statements)

References 121 publications

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“…Although the immunologic perspective toward RA is typically limited to how RA is initiated (i.e., by failure of immunological tolerance) and its resultant synovitis (the conventional definition of disease culmination), a hallmark of RA is the rapid erosion of periarticular bone, which is often followed by general secondary osteoporosis (or osteopenia). OCs are found to be prevalent at the site of focal erosion and are critical for bone erosion (49,50).…”

Section: Interplay Between Ocs and The Immune Systemmentioning

confidence: 99%

“…In addition to arthritis, periodontal disease, and inflammatory bowel disease, pathologic bone loss is observed in patients suffering from other autoimmune diseases (diabetes mellitus and lupus erythematosus), chronic viral infections (HIV), allergic diseases (asthma), and metastatic breast and lung cancers (49,50,119). The contribution to pathogeneses by osteoimmunologic factors merits further investigation and may provide viable therapeutic options for alleviating painful sequelae associated with a variety of conditions.…”

Section: Autoimmunity Bone and Trance: The Birth Of Osteoimmunologymentioning

confidence: 99%

“…T cells also secrete cytokines, such as IFN-γ, IL-4, and TGF-β, that inhibit the pro-osteoclastogenic effects of TRANCE (48)(49)(50) (Figure 4). The role of the Th1 cytokine IFN-γ, in particular, appears to be www.annualreviews.org • Insights into Osteoimmunology TLR: Toll-like receptor crucial in preventing T lymphocyte-mediated osteoclastogenesis (120).…”

Section: Autoimmunity Bone and Trance: The Birth Of Osteoimmunologymentioning

confidence: 99%

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OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

Walsh

Kim

Kadono

et al. 2006

Annu. Rev. Immunol.

631

567

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Studies of bone and the immune system have converged in recent years under the banner of osteoimmunology. The immune system is spawned in the bone marrow reservoir, and investigators now recognize that important niches also exist there for memory lymphocytes. At the same time, various factors produced during immune responses are capable of profoundly affecting regulation of bone. Mechanisms have evolved to prevent excessive interference by the immune system with bone homeostasis, yet pathologic bone loss is a common sequela associated with autoimmunity and cancer. There are also developmental links, or parallels, between bone and the immune system. Cells that regulate bone turnover share a common precursor with inflammatory immune cells and may restrict themselves anatomically, in part by utilizing a signaling network analogous to lymphocyte costimulation. Efforts are currently under way to further characterize how these two organ systems overlap and to develop therapeutic strategies that benefit from this understanding.

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Section: Interplay Between Ocs and The Immune Systemmentioning

confidence: 99%

Section: Autoimmunity Bone and Trance: The Birth Of Osteoimmunologymentioning

confidence: 99%

Section: Autoimmunity Bone and Trance: The Birth Of Osteoimmunologymentioning

confidence: 99%

See 1 more Smart Citation

OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

Walsh

Kim

Kadono

et al. 2006

Annu. Rev. Immunol.

631

567

View full text Add to dashboard Cite

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“…This area of research is particularly important for the comprehension of the mechanisms underlying the profound alterations of bone architecture caused by immune activation in inflammatory diseases [22]. The word osteoimmunology is rather original.…”

Section: Introductionmentioning

confidence: 99%

The Tight Relationship Between Osteoclasts and the Immune System

Fattore¹,

Teti

2012

IADT

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Osteoimmunology is an interdisciplinary field addressing the interplay between the skeletal and the immune system. A substantial body of evidence demonstrated the existence of two-way regulatory mechanisms that affect both systems, placing them in much closer association to each other than one could ever predict. Inflammatory diseases have long been known to induce alterations in bone metabolism, and inflammatory cytokines play prominent roles in the control of bone resorption, representing communication pathways bridging the two systems. Osteoclasts are particularly linked to the immune cells because they belong to the monocyte/macrophage family, have tight relationships with B and T cells, and differentiate in response to RANKL which is also produced by lymphocytes and regulates lymphopoiesis. Osteoclasts are negatively regulated by cytokines and other factors known for their anti-inflammatory and immune regulatory activity. Finally, they express immune co-receptor typical of immune cells which are indispensable for their differentiation, thus leading to the hypothesis that osteoclasts are immune cells themselves. The underlying principle why an immune cell is required to resorb bone has not yet been elucidated. Data from early literature suggest that the bone matrix could trigger an innate immune response activating giant cells that could destroy large bone areas because of their unique property of resorbing bone extracellularly. Bone resorption could though be prevented by the physical barrier made by osteoblasts and lining cells, whose retraction would be required to give access to osteoclasts when specific pathways signal their precursors to differentiate and mature osteoclasts to reach the uncovered bone surface.

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“…Agentes terapêuticos novos que interferem na ação da osteoprotegerina têm sido descobertos, incluindo peptídeos cíclicos que inibem a ação do TNF-α e bloqueiam a osteoclastogênese induzida pelo RANKL. Estes agentes novos têm uma maior afinidade para a forma solúvel do RANKL, podendo assim determinar seletividade nos quadros de reabsorção óssea patológica (53,54) .…”

Section: Erosões óSseas Subcondraisunclassified

Osteoporose e erosões osseas focais na artrite reumatóide: da patogênese ao tratamento

Pereira¹,

Pereira²

2004

Rev. Bras. Reumatol.

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Rev Bras Reumatol, v. 44, n. INTRODUÇÃOA artrite reumatóide afeta aproximadamente 0,5% a 1% da população e determina um custo social e econômico importante, considerando o grau de incapacidade para o trabalho e também o aumento da mortalidade decorrente desta doença (1,2,3) . O envolvimento ósseo na artrite reumatóide inclui a osteopenia justa-articular, as erosões ósseas e a osteoporose generalizada que acomete tanto o esqueleto axial quanto o esqueleto apendicular. A osteoporose constitui um problema clínico importante nos pacientes com artrite reumatóide, acometendo 30% a 50% dos pacientes, mesmo que estes não tenham utilizado corticosteróides, tendo como conseqüência um aumento importante do número de fraturas (4,5) .

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T-cell involvement in osteoclast biology: implications for rheumatoid bone erosion

Cited by 30 publications

References 121 publications

OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

The Tight Relationship Between Osteoclasts and the Immune System

Osteoporose e erosões osseas focais na artrite reumatóide: da patogênese ao tratamento

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