T cell-loaded injectable chitosan scaffold shows short-term efficacy in localised cancer immunotherapy in mice

Abstract

Adoptive cell therapy (ACT) shows success against treatment-resistant cancers, but is limited by the large number of intravenously-delivered T cells required and toxicity related to systemic administration. In this work,...

Biomaterial-Based Sustained-Release Drug Formulations for Localized Cancer Immunotherapy

“…These biomaterials can form in situ drug depots simply by needle injection, avoid undesired deconstruction, and ensure long-term applications, supporting their feasibility and efficacy for local drug delivery. 176,177 In addition, high flexibility and elasticity can render reversible shape deconformation of 3D scaffolds in response to local environments in the body, which can enhance target access by altering the morphology to be able to cross surrounding environments toward the target sites. 178,179 The high surface area-to-volume ratio of porous structures is not only beneficial for drug loading but also facilitates drug release with the rate largely depending on the mechanical property: low or high elastic modulus results in a less or more malleable and deformable matrix, influences the size, distribution, and 3D connectivity of the pore structures and the associated drug release behavior.…”

“…Biomaterials that are viscoelastically soft in nature and exhibit robust mechanical strength with an appropriate balance of tensile strength and modulus can provide a promising drug delivery platform. These biomaterials can form in situ drug depots simply by needle injection, avoid undesired deconstruction, and ensure long-term applications, supporting their feasibility and efficacy for local drug delivery. , In addition, high flexibility and elasticity can render reversible shape deconformation of 3D scaffolds in response to local environments in the body, which can enhance target access by altering the morphology to be able to cross surrounding environments toward the target sites. , The high surface area-to-volume ratio of porous structures is not only beneficial for drug loading but also facilitates drug release with the rate largely depending on the mechanical property: low or high elastic modulus results in a less or more malleable and deformable matrix, influences the size, distribution, and 3D connectivity of the pore structures and the associated drug release behavior . Notably, rigid inorganic scaffolds can provide a robust platform for in situ formation of 3D microporous structure via spontaneous interparticle assembly; high aspect ratio MSRs can create interconnected micropores upon in vivo injection, which can serve as a local immune cell niche .…”