T-Cell Lymphoma Presenting in the Breast: A Histologic, Immunophenotypic and Molecular Genetic Study of Four Cases

Aguilera, Nadine S.; Tavassoli, Fattaneh A.; Chu, Wei‐Sing; Abbondanzo, Susan L.

doi:10.1038/modpathol.3880103

Cited by 52 publications

(32 citation statements)

References 43 publications

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“…The majority of breast NHLs are of B-cell phenotype, with the frequency of T-cell NHLs ranging from 2.5-7.5% [11][12][13][14]. Several types of T-cell NHL have been reported in the breast, including anaplastic large-cell lymphoma, peripheral T-cell lymphoma not otherwise specified (NOS), adult T-cell lymphoma/leukemia (ATLL), and NK/ T-cell lymphoma [15,16].…”

Section: Discussionmentioning

confidence: 99%

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

et al. 2005

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Non-Hodgkin lymphoma of T-cell lineage involving the breast is rare. We report on a 41-year-old woman with T-cell lymphoblastic lymphoma who presented with multiple bilateral breast masses. The patient was treated with intensive chemotherapy and mediastinal and whole-brain irradiation. She remains in complete remission 24 months after diagnosis. The clinical, histologic, phenotypic, and cytogenetic features are described, with a review of the literature. Am.

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Section: Discussionmentioning

confidence: 99%

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

et al. 2005

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“…In all cases diffuse large cell and B-cell phenotypes were confirmed. Because other histologies have varying clinical evolution, we excluded patients with T-cell phenotype or mucosa-associated lymphoid tissue of the breast [10,11,12]. …”

Section: Methodsmentioning

confidence: 99%

Primary Breast Lymphoma: Results of a Controlled Clinical Trial

Avilés¹,

et al. 2005

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Objectives: To assess the efficacy and toxicity of the most employed therapeutic approaches in the treatment of primary breast lymphoma (PBL). Methods: Ninety-six patients with PBL in the early stage (I or II) were enrolled to receive radiotherapy (45 Gy); chemotherapy (six cycles of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), every 21 days), or combined therapy. Results: Complete response was achieved in 20 of 30 patients treated with radiotherapy, 19 of 32 who were treated with chemotherapy and 30 of 34 in the combined arm (p < 0.01). Actuarial curves at 10 years showed that event-free survival was 50, 57 and 83%, respectively (p < 0.01). Actuarial curves for overall survival were 50, 50 and 76% (p < 0.01), respectively. The most common site of relapse was the central nervous system. Acute toxicity was mild. Until now, no second neoplasm or acute leukemia has been observed. Conclusions: In our study combined therapy is the best treatment in this special setting of patients; with improvement in event-free survival and overall survival without acute or severe late side effects. Prophylaxis to the central nervous system will be considered in the initial treatment to improve outcome.

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“…T-cell lymphomas of the breast have been reported rarely, and few of these occur without an associated implant. 3,4 In recent years, there have been several case reports of patients developing lymphomas in close proximity to silicone or saline breast implants. [5][6][7][8][9][10][11][12][13] Interestingly, the majority of implant-associated lymphomas were T-cell lymphomas, including anaplastic large-cell lymphoma (n ¼ 5) [5][6][7]13 and mycosis fungoides/Sézary syndrome (n ¼ 4).…”

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confidence: 99%

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

et al. 2008

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Non-Hodgkin lymphomas of the breast are rare, encompassing approximately 0.04-0.5% of all malignant breast tumors, and the vast majority are B-cell lymphomas. In contrast, lymphomas of T-cell phenotype have been rarely reported and some of these have been in close proximity to a breast implant. In our consultation practice, we have identified four patients with primary T-cell anaplastic large-cell lymphoma presenting adjacent to silicone or saline breast implants. All patients presented with seroma and neoplastic cells were identified in suspension in the serous fluid without solid tissue invasion. Three patients had no evidence of systemic disease (stage 1E), and one patient was not staged. The mean age of the patients was 46 years (range, 34-59 years). In all patients, the neoplastic cells had a T-cell phenotype, expressed CD30, cytotoxic granuleassociated proteins, EMA and clusterin, and were anaplastic lymphoma kinase-1-negative. Clonal T-cell receptor c-chain gene rearrangements were identified in three patients. All patients underwent capsulectomy with removal of the implant. One patient subsequently received chemotherapy and radiation therapy, and another was treated with radiation alone. The third patient received no further therapy and the fourth patient has been recently diagnosed. After a mean time of 13 months (range, 9-20 months), all three patients with follow-up were alive and well without any recurrence or systemic disease. Although the follow-up time was relatively short, our series and other reported cases suggest that primary anaplastic large-cell lymphoma adjacent to breast implants is an indolent T-cell lymphoproliferative disorder. Keywords: anaplastic large-cell lymphoma; primary lymphoma of breast; breast implant; silicone; saline Non-Hodgkin lymphomas of the breast are rare and comprise approximately 0.04-0.5% of all malignant breast tumors and 2.2% of extranodal lymphomas.

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T-Cell Lymphoma Presenting in the Breast: A Histologic, Immunophenotypic and Molecular Genetic Study of Four Cases

Cited by 52 publications

References 43 publications

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

Primary Breast Lymphoma: Results of a Controlled Clinical Trial

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

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