T-Cell Lymphoma Showing a Non-Enhancing Diffuse White Matter Lesion with Marked Brain Atrophy.

Abstract

Wereport an autopsy case of T-cell lymphomawith diffuse white matter infiltration. Cranial magnetic resonance (MR) images showed atrophy of the brain with a diffuse, non-enhancing, T2-high signal intensity lesion in the cerebral white matter. Intra-axial infiltration of T-cell lymphoma should be considered a differential diagnosis in patients with these MRIfindings. (Internal Medicine 38: 507-511, 1999)

Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study

“…Primary central nervous system lymphoma (PCNSL) sometimes looks like PML on MRI, with abnormalities confined to the white matter and devoid of a mass effect. A few cases of PCNSL showed non enhancing mass lesions [ 6 – 8 ]…”

“…Primary central nervous system lymphoma (PCNSL) sometimes looks like PML on MRI, with abnormalities confined to the white matter and devoid of a mass effect. A few cases of PCNSL showed non enhancing mass lesions [6][7][8] Moreover, PCNSL, like PML, occurs with immunosuppression [9], and an association between these two diseases has been described [10]. Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, accounting for approximately 15% of all intra-cranial tumors [11], and PML can rarely mimic multifocal glioma progression on MRI [12].…”