T cell‐mediated immunity to oncornavirus‐induced tumors IV. Preliminary evidence for a specific suppression of anti‐Moloney cell‐mediated immune response by autoimmune T cells

Leclerc, J. C.; Plater, Christine; Connan, Francine; Debré, Patrice

doi:10.1002/eji.1830110110

Cited by 4 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ts cells should also be defined as described in another tumor system [lo], with regard to other cell surface markers, and in particular the I-J antigen. It would be also useful to know whether or not these Ts cells belong to the same T cell subset as the auto-anti-MSV T blasts described in the following report [28]. Another functional determination of importance would be the evaluation of their effect on helper T cells.…”

Section: Discussionmentioning

confidence: 97%

T cell‐mediated immunity to oncornavirus‐induced tumors III. Specific and nonspecific suppression in tumor‐bearing mice

1981

Self Cite

View full text Add to dashboard Cite

A strong cell-mediated immune response against Friend, Moloney, Rauscher virus-induced (FMR) cell surface antigens has been demonstrated previously in mice which reject oncornavirus-induced tumors. In order to identify an eventual suppressor mechanism in animals with progressively growing tumors, experiments were initiated in C57BL/6 mice bearing either a murine sarcoma virus (MSV) tumor or Moloney virus-induced lymphoma (MBL2). Progressive tumor growth was induced (a) in viremic animals first infected with Moloney murine leukemia virus (M.Mu LV), then inoculated as adult with MSV; (b) in nonviremic animals injected with MBL2 lymphoma cells. In the absence of tumor cells, viremia induces specific tolerance for which there is no evidence for suppressor cells. In tumor-bearing mice, specific suppressor T cells are detected which are able to inhibit the generation of anti-FMR cytolytic T lymphocytes in vitro and enhance the tumor growth in vivo. In addition to the specific suppressor T cells, a nonspecific suppressive activity mediated by metastatic T lymphoma cells is demonstrated in the spleens of lymphoma-bearing animals. The respective role of the virus and tumor cells in the induction of tolerance to M.MuLV-induced antigens, and their relationship to other components of the specific cell-mediated immune response is discussed.

show abstract

Section: Discussionmentioning

confidence: 97%

T cell‐mediated immunity to oncornavirus‐induced tumors III. Specific and nonspecific suppression in tumor‐bearing mice

1981

Self Cite

View full text Add to dashboard Cite

show abstract

Suppressor Cells and Malignancy

Naor¹,

Duke‐Cohan²

1986

Advances in Immunity and Cancer Therapy

View full text Add to dashboard Cite

Treatment of spinal epidural neuroblastoma xenografts in rats using anti-GD2 monoclonal antibody 3F8

et al. 1993

View full text Add to dashboard Cite

Epidural neuroblastoma xenografts in nude rats causing paraparesis were treated with intravenous injection of an anti-GD2 monoclonal antibody 3F8. Metastatic or primary epidural tumors in humans cause rapid neurologic compromise. Treatment is often unsatisfactory. An animal model was established to study antibody targeted therapy of epidural tumor. Human neuroblastoma was xenotransplanted into the thoracic epidural space of nude rats. When paraparesis developed, animals were treated intravenously with an anti-GD2 monoclonal antibody, 3F8, either alone or radiolabeled with 131Iodine. Improvement in neurologic function occurred in 2 of 20 (10%) animals receiving no treatment or control antibody, 14 of 17 (82%) animals receiving 3F8 alone and all 9 animals receiving 131I-3F8 (p < 0.0001 for 3F8 or 131I-3F8 vs. control). Six animals treated with 3F8 alone recovered normal neurologic function and remained well until sacrifice 10 days later. Four animals treated with 3F8 alone had no tumor evident on pathologic examination. The percent injected dose of 131I-3F8/g tumor in 5 samples ranged from 0.73% to 3.8%. These observations demonstrate that neoplastic epidural compression of the spinal cord in the rat can be treated successfully with intravenous unmodified monoclonal antibody and that signs of neurologic dysfunction can be reversed. The potential of this approach in treating patients with epidural tumors and other neoplasms, especially those that are not sensitive to chemotherapy or radiotherapy, deserves to be explored.

show abstract

T cell‐mediated immunity to oncornavirus‐induced tumors IV. Preliminary evidence for a specific suppression of anti‐Moloney cell‐mediated immune response by autoimmune T cells

Cited by 4 publications

References 23 publications

T cell‐mediated immunity to oncornavirus‐induced tumors III. Specific and nonspecific suppression in tumor‐bearing mice

T cell‐mediated immunity to oncornavirus‐induced tumors III. Specific and nonspecific suppression in tumor‐bearing mice

Suppressor Cells and Malignancy

Treatment of spinal epidural neuroblastoma xenografts in rats using anti-GD2 monoclonal antibody 3F8

Contact Info

Product

Resources

About