T cell non-Hodgkin's lymphoma with uveitis, pancreatitis, digital gangrene and multiple chromosomal abnormalities.

Mansour, Paul; Adams, R. D.; P, Isaacs; Ridway, J C; Flanagan, N. G.; Harrison, Christine J.

doi:10.1136/jcp.43.8.694-b

Cited by 5 publications

(3 citation statements)

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“…The acral vascular syndromes can cooccur, predate, or present after the diagnosis of malignancy [ 32 ]. Although an uncommon finding with sparse data in the literature, digital ischemia may occur as a paraneoplastic feature of T cell non-Hodgkin lymphoma [ 33 , 34 ]. The pathophysiology of paraneoplastic vascular syndrome is poorly understood and likely to be multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Digital Gangrene: An Unusual Manifestation of Non-Hodgkin Lymphoma

Majumder

Ahmed

Haque

et al. 2022

Case Reports in Vascular Medicine

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Background. Non-Hodgkin lymphomas (NHLs) comprise a group of haematologic malignancies with different histologic subtypes. The clinical picture varies from indolent to aggressive presentation and nodal (lymphadenopathy) to extranodal (central nervous system, gastrointestinal, cutaneous plaque, or ulcer) involvement. Digital gangrene is seldom reported. Here, we describe a patient with pain and blackening of all fingers and toes as presenting symptoms of NHL. Case Presentation. A 32-year-old male weaver had been smoking three to five cannabis-containing cigarettes daily for about ten years and methamphetamine four to five tablets daily for five years. He had no history of Raynaud’s phenomenon, fever, cough, weight loss, skin rash, joint pain, and atherogenic or thrombogenic risk factors. We found normal blood pressure and absent peripheral pulses in arms and legs, dry gangrene of all fingers and toes, generalized lymphadenopathy, and hepatomegaly with ascites. The chest X-ray was normal, as were blood sugar, lipid profile, and hepatic and renal function. Rheumatoid factor, antinuclear and antiphospholipid antibodies, C-ANCA and P-ANCA, hepatitis B and C, and HIV were negative. CT abdomen revealed hepatosplenomegaly with multiple intra-abdominal lymphadenopathies. The peripheral angiogram showed 90-99% stenosis of radial and dorsalis pedis arteries with normal proximal vessels. Diagnosis of non-Hodgkin lymphoma was confirmed by histopathology of cervical lymph node (diffuse type), immunohistochemically subtyped as peripheral T cell lymphoma (not otherwise specified). The digital ischemia worsened despite cessation of cannabis and methamphetamine and starting CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) treatment, making amputation necessary. Conclusion. We present, to our knowledge, the first report of peripheral T cell lymphoma, NOS presenting with gangrene in all digits complicated by methamphetamine and cannabis abuse. This uncommon vascular manifestation of non-Hodgkin lymphoma may cause a diagnostic dilemma and delayed initiation of treatment.

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Section: Discussionmentioning

confidence: 99%

Digital Gangrene: An Unusual Manifestation of Non-Hodgkin Lymphoma

Majumder

Ahmed

Haque

et al. 2022

Case Reports in Vascular Medicine

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“…Podría tratarse de un evento aislado y sin relación con el LNH. Se describen algunos casos de aparición de pancreatitis asociada a LNH sin afectación tumoral pancreática (5,6). Takahashi y cols 7, atribuyen una posible causa inmune a la aparición de algunas pancreatitis en el contexto del LNH denominando el cuadro clínico "pancreatitis autoinmune".…”

Section: Discussionunclassified

Linfoma No-Hodgkin y pancreatitis aguda en gestante: reporte de caso

H¹,

B²,

T³

et al. 2016

Rev. chil. obstet. ginecol.

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El linfoma no Hodgkin durante el embarazo es una entidad rara, el tipo difuso de células grandes es aún menos frecuente y se caracteriza por una alta tasa de progresión tumoral con poca expresión clínica. Su diagnóstico y tratamiento representan un reto clínico debido a la baja incidencia de la enfermedad y a las posibles repercusiones fetales a causa del tratamiento. Caso clínico: Gestante secundípara de 31 años que ingresa por cuadro de dolor abdominal y cifras elevadas de lactato deshidrogenasa. Durante la gestación precisa varios ingresos por pancreatitis aguda de repetición y cuadro de colestasis intrahepática. Tras el parto evoluciona tórpidamente con aparición de edema en esclavina en cuello y miembros superiores, siendo diagnosticada de gran masa torácica cuya biopsia es informada como Linfoma No Hodgkin tipo B difuso de células grandes primario mediastinal. Se administran dos ciclos de tratamiento quimioterápico tras lo cual remite completamente la enfermedad. Se induce el parto con prostaglandinas intravaginal, con recién nacido de 3350 gramos y APGAR 8/10. Tras un año la paciente permanece en remisión completa.

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“…. De rares cas sont décrits au cours d'hémopathies, telles que des myélomes [8], des lymphomes non hodgkiniens [9]. À notre connaissance, il n'existe pas de série groupant des cas de nécroses digitales paranéoplasiques, et uniquement deux cas de nécroses digitales ont déjà été rapportées à une MH [10,11].…”

Section: Discussionunclassified