T‐cell positioning by chemokines in autoimmune skin diseases

Richmond, Julius B.; Strassner, James P.; Essien, Kingsley I.; Harris, John E.

doi:10.1111/imr.12762

Cited by 31 publications

(23 citation statements)

References 316 publications

(317 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CXCL10/IP-10 has previously been described as increasing with age in studies with shorter follow-up time (Hearps et al, 2012; Hsu et al, 2019). Also CCL27/C-TACK levels increased with age in men and women, possibly related to accumulating skin damage in elderly, since CCL27/C-TACK is a cytokine involved in T-cell-mediated homing to the skin (Homey et al, 2002; Richmond et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study

Samson

Buisman

et al. 2021

Preprint

View full text Add to dashboard Cite

Little is known about the development of low-grade inflammation with age and its relationship with the onset of frailty. In this exploratory study, we investigated 18 inflammatory markers measured in blood of 148 individuals aged 65-75 years at study endpoint, collected over 20 years at five-year intervals. IFNγ- and platelet activation markers changed in synchrony over time. Chronically elevated levels of IL-6-related markers, such as CRP and sIL-6R, were associated with frailty and becoming frail over time, ,poorer lung function or less physical strength. Overweight was a possible driver of these associations. More and stronger associations were detected in women, such as between increasing sCD14 levels and frailty, indicating possible monocyte overactivation. Multivariate prediction of frailty showed low accuracy but confirmed the main results. In summary, we documented 20-year temporal changes in and between inflammatory markers in an aging population, and related these to clinically relevant health outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study

Samson

Buisman

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Also, CCL27 levels increased with age. This is possibly related to an accumulation of skin damage, since CCL27 is a cytokine involved in T‐cell‐mediated homing to the skin 16,17 …”

Section: Discussionmentioning

confidence: 99%

Inflammatory marker trajectories associated with frailty and ageing in a 20‐year longitudinal study

et al. 2022

View full text Add to dashboard Cite

Objective The aim of this exploratory study was to investigate the development of low‐grade inflammation during ageing and its relationship with frailty. Methods The trajectories of 18 inflammatory markers measured in blood samples, collected at 5‐year intervals over a period of 20 years from 144 individuals aged 65–75 years at the study endpoint, were related to the degree of frailty later in life. Results IFN‐γ‐related markers and platelet activation markers were found to change in synchrony. Chronically elevated levels of IL‐6 pathway markers, such as CRP and sIL‐6R, were associated with more frailty, poorer lung function and reduced physical strength. Being overweight was a possible driver of these associations. More and stronger associations were detected in women, such as a relation between increasing sCD14 levels and frailty, indicating a possible role for monocyte overactivation. Multivariate prediction of frailty confirmed the main results, but predictive accuracy was low. Conclusion In summary, we documented temporal changes in and between inflammatory markers in an ageing population over a period of 20 years, and related these to clinically relevant health outcomes.

show abstract

“…The deficiency of TSLP gene results in the dominance of the Th1 immune response and further activates the IFN- γ -CXCL10 axis [ 9 ]. Researchers using genome-wide profiling revealed the vitiligo blood transcriptomics and found involvement of STAT1/IRF9, which also reinforced the important role of the IFN- γ -chemokine axis [ 36 ]. Analysis of gene expression profiling revealed the elevations of IFN- γ and IFN- γ -induced genes in the serum and lesional skin from patients with vitiligo and mouse models of vitiligo, and researchers found that the IFN- γ levels were correlated with the progression and maintenance of vitiligo, indicating that IFN- γ could serve as a reliable risk factor in vitiligo patients [ 37 – 42 ].…”

Section: Interaction Between Chemokines and Oxidative Stress In The Development Of Vitiligomentioning

confidence: 99%

The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response

2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Vitiligo is a common chronic autoimmune skin disorder featured with depigmented patches and underlying destruction of melanocytes in the lesional skin. Multiple factors and mechanisms have been proposed for the etiopathogenesis of vitiligo, among which oxidative stress has been widely accepted as a key factor in initiating melanocyte loss. The altered redox status caused by oxidative stress, including the overproduction of reactive oxygen species (ROS) and the decreased activity of the antioxidant system in the skin, surrenders the resistance of melanocytes to exogenous or endogenous stimuli and eventually impairs the normal defense mechanism, leading to the absence of melanocytes. Considering the important role of innate and adaptive immunity in vitiligo, there is mounting evidence revealing an association between oxidative stress and autoimmunity. Since the significant changes of chemokines have been documented in vitiligo in many recent studies, it has been suggested that ROS-mediated chemotactic signals are not only the biomarkers of disease progression and prognosis but also are involved in the pathogenesis of vitiligo by facilitating the innate and adaptive immune cells, especially melanocyte-specific T cells, trafficking to the lesional areas of vitiligo. In this review, we discuss the interaction between oxidative stress and autoimmune response orchestrated by chemokines, including CXCL16-CXCR6 axis, CXCL9/CXCL10-CXCR3 axis, and other altered chemokines in vitiligo, and we also try to provide insight into potential therapeutic options through targeting these pathways.

show abstract

T‐cell positioning by chemokines in autoimmune skin diseases

Cited by 31 publications

References 316 publications

Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study

Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study

Inflammatory marker trajectories associated with frailty and ageing in a 20‐year longitudinal study

The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response

Contact Info

Product

Resources

About