“T-Cell-Rich B-Cell Lymphoproliferative Disorder” of the Bone Marrow

Abstract

We report four cases of a "T-cell-rich B-cell chronic lymphoproliferative disorder" involving the bone marrow and not extramedullary sites. The neoplastic B-cell proliferation in these cases was composed predominantly of small lymphoid cells with features of both hairy cell leukemia and lymphoplasmacytoid lymphoma. All cases presented with neutropenia and with difficulty in diagnosis. We present the clinical, morphologic, cytochemical, and immunophenotypic findings in these cases and discuss this entity.

Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement

“…Bone marrow involvement by TCHRLBCL has never been reported in children, although it is frequent among adults consistent with the high frequency of advanced disease [2,4,20]. In fact, four cases with primary bone marrow involvement with Tcell-rich B-cell lymphoproliferative disease have been reported [21]. However, in the pediatric cases, this lymphoma tends to be a local disease.…”