T-cell subsets and natural killer activity in Plasmodium falciparum-infected children

Stach, J L; Dufrenoy, E.; Roffi, J; Bach, Marie‐Anne

doi:10.1016/0090-1229(86)90130-3

Cited by 23 publications

(10 citation statements)

References 12 publications

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“…Similar findings have been reported previously by Gross et al (13) in mice and Stach et al (14) in humans. The rise in CD8+ cell percentage was attributed to the increase in T suppressor cells (13).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Quantitative estimation of suppressor/cytotoxic and helper T cells during acute and chronic Plasmodium berghei infection

Wangoo

Kaur

Ganguly

et al. 1990

Immunology & Cell Biology

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SummaryIn the present study, the percentage of lymphocyte subpopuiations and their relation to T cell subsets was estimated during acute and chronic Plasmodium berghei malaria. During acute infection, a decreased percentage of T lymphocytes was observed, whereas no change was observed during chronic infection. However, no change in the percentage of B cells was observed in both types of infection. The T cell population was characterized by an increased percentage of T suppressor cytotoxic (CD8+) cells and a decreased percentage of T helper cells (CD4+) during acute infection. This resulted in an inversion ofthe CD8+/CD4+ cell ratio. During chronic infection no change in the CD8'*" cell percentage was observed; however some increase in CD4+ cell percentage was observed in later stages. Thus failure ofthe immune system to overcome acute infection may be due to an increase in T suppressor cells, and maintenance of parasites at subpatent levels during chronic infection may involve the normal CD8+/CD4+ cell ratio with some increase in CD4+ cells.

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Section: Discussionsupporting

confidence: 92%

“…Therefore direct evidence for an alteration in the number of T helper and T suppressor cells is necessary. Recently Gross et al (13) in mice and Stach et al (14) in humans have shown an increase in T suppressor cells during acute malaria infection. However, studies during chronic infection are lacking.…”

Section: Introductionmentioning

confidence: 98%

Quantitative estimation of suppressor/cytotoxic and helper T cells during acute and chronic Plasmodium berghei infection

Wangoo

Kaur

Ganguly

et al. 1990

Immunology & Cell Biology

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“…Moreover, the activation status of gd + as well as non-gd + T cells was not evaluated. Few studies on human lymphocyte subpopulation analyses have been conducted in malaria patients, with variable results [8,[11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte activation and subset redistribution in the peripheral blood in acute malaria illness: distinct γδ+ T cell patterns in Plasmodium falciparum and P. vivax infections

Worku

Björkman

Troye‐Blomberg

et al. 1997

Clinical and Experimental Immunology

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SUMMARYLymphocyte subset distributions and activation in the peripheral blood were studied in 39 patients with acute malaria and 16 healthy controls from Addis Ababa and Nazareth, Ethiopia. As confirmed by polymerase chain reaction (PCR), 15 patients were infected with Plasmodium falciparum (Pf ), 17 with P. vivax (Pv) and seven were double-infected (Di) with both Pf and Pv. Three-colour flow cytometry was used for phenotyping. Total leucocyte and lymphocyte counts were lower in malaria patients than in controls. The T cell count was reduced in Pf patients, while in the Pv and Di patients there was a reduction in the natural killer (NK) cell count. The CD4/CD8 ratio remained unchanged. gd + T cells were significantly elevated in Pf and Di patients, but not in Pv patients. The increase in gd + T cells was mostly due to an increase in Vd1 + cells. Analyses of cellular activation indicated by the expressions of CD25 and HLA-DR revealed significantly higher numbers of activated CD3 + cells, including gd + T cells, in all patient groups compared with controls. Our results thus indicate that in acute malaria illness there is a complex pattern of change in lymphocyte subset distribution and activation, including gd + T cells. These patterns in Pf infection seem to be distinct from those in Pv infection.

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“…In 1986, Stach et al (37) described that NK cell cytotoxic function was normal in benign uncomplicated malaria, whereas it was severely decreased in children with cerebral malaria. In a mouse model of malaria induced by Plasmodium berghei ANKA, it was shown that the NK cell complex genetically influences pathogenesis, that NK cells are necessary for both disease pathogenesis and control of parasitemia, and that NK cells infiltrate the brain of mice with cerebral malaria (38).…”

Section: Nk Cell Modifications Associated With Cns Disordersmentioning

confidence: 99%

NK Cells in Central Nervous System Disorders

Poli

Kmiecik

Domingues

et al. 2013

The Journal of Immunology

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NK cells are important players in immunity against pathogens and neoplasms. As a component of the innate immune system, they are one of the first effectors on sites of inflammation. Through their cytokine production capacities, NK cells participate in the development of a potent adaptive immune response. Furthermore, NK cells were found to have regulatory functions to limit and prevent autoimmunity via killing of autologous immune cells. These paradoxical functions of NK cells are reflected in CNS disorders. In this review, we discuss the phenotypes and functional features of peripheral and brain NK cells in brain tumors and infections, neurodegenerative diseases, acute vascular and traumatic damage, as well as mental disorders. We also discuss the implication of NK cells in neurotoxicity and neuroprotection following CNS pathology, as well as the crosstalk between NK cells and brain-resident immune cells.

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T-cell subsets and natural killer activity in Plasmodium falciparum-infected children

Cited by 23 publications

References 12 publications

Quantitative estimation of suppressor/cytotoxic and helper T cells during acute and chronic Plasmodium berghei infection

Quantitative estimation of suppressor/cytotoxic and helper T cells during acute and chronic Plasmodium berghei infection

Lymphocyte activation and subset redistribution in the peripheral blood in acute malaria illness: distinct γδ+ T cell patterns in Plasmodium falciparum and P. vivax infections

NK Cells in Central Nervous System Disorders

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