T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma

Rahman, Atiqur; Islam, Shofikul; Tony, S.; Siddique, Abu Eabrahim; Mondal, Victor; Hosen, Zubaer; Islam, Zohurul; Hossain, I.; Rahman, Mizanur; Anjum, Adeeba; Paul, Sudip; Hossen, Faruk; Sarker, Khalequzzaman; Hossain, Sabbir; Salam, Kazi Abdus; Haque, Azizul; Hoque, Ashraful; Saud, Zahangir Alam; Lian, Xin; Sumi, Daigo; Himeno, Seiichiro; Hossain, Khaled

doi:10.1016/j.taap.2021.115532

Cited by 20 publications

(22 citation statements)

References 67 publications

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“…They also reported that intermediate (5.32–134 μg/L) and high (135–1800 μg/L) exposure levels of arsenic in water were associated with the level of serum IgE (β = 0.127; 95%CI [0.023–0.231] and β = 0.237; 95%CI [0.109–0.36], respectively). Similar results were obtained when evaluating arsenic exposure in hair and nails [ 18 ]. The authors also reported that type 2 cytokines increased with a higher concentration of arsenic in drinking water, hair, and nails [ 18 ].…”

Section: Discussionsupporting

confidence: 83%

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Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Muñoz

Iglesias

Saavedra

et al. 2022

Toxics

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In the city of Arica, northern Chile, the population has been involuntarily exposed to arsenic of natural and anthropogenic origin. This study aims to evaluate the association between urinary arsenic concentration and bronchial asthma diagnosis in the children of Arica. A cross-sectional analysis of a database of 1892 subjects under 18 years of age enrolled in the Environmental Health Centre between 2009 and 2021 was carried out. Arsenic exposure was obtained from a urine sample and bronchial asthma diagnosis from the database of the system for the management of explicit health guarantees. Logistic regression models were used to assess the association between inorganic arsenic and asthma. The median inorganic arsenic was 15 μg/L, and the prevalence of asthma was 7.4%. After adjusting for sex, age, ethnicity, and urinary creatinine, children with the highest tertile of urinary arsenic concentration (≥21.4 μg/L) had a greater chance of developing asthma (odds ratio (OR) 1.90; 95% confidence interval (CI) [1.13–3.18]). When exploring the modifying effect of ethnicity, the association increased among children belonging to any ethnic group (OR 3.51, 95%CI [1.43–8.65]). These findings suggest a relationship between arsenic exposure and bronchial asthma in children. While further studies are needed to assess the impact of arsenic on respiratory health, mitigation efforts to reduce arsenic exposure should be maintained.

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Section: Discussionsupporting

confidence: 83%

“…The susceptibility to developing arsenic-induced asthma is supported by its modulating effect on the immune system. Two studies have noted that arsenic exposure is related to asthma of allergic origin in adults, as arsenic was positively associated with serum levels of Immunoglobulin E (IgE) [ 17 ] and type 2 cytokines (Th2) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Muñoz

Iglesias

Saavedra

et al. 2022

Toxics

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“…Our studies have shown that As can elevate IL-1β [ 14 ], suggesting that As exposure induces a proinflammatory state. Depending upon the dose, duration, and timing of exposure, As may elevate certain immune biomarkers, including some human antibody subsets [ 45 , 46 ] and cytokines, including Th2-mediators- interleukin (IL)-4, IL-5, IL-13, and eotaxins [ 47 ]. Thus, the effects of As on the human immune system in vivo is quite complex and its effects can also depend on other environmental and nutritional conditions.…”

Section: Discussionmentioning

confidence: 99%

Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults

et al. 2022

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There is limited evidence on the effects of environmental exposure to arsenic (As) on the immune system in adults. In a population-based study, we have found that urinary As (UAs), and its metabolites [inorganic As (InAs), monomethylated arsenicals (MMA+3/+5), and dimethylated arsenicals (DMA+3/+5)] modulate or influence the number of T-helper 17 (Th17) cells and IL-17A cytokine production. In non-smoking women, we observed that UAs and DMA+3/+5 were associated with changes in Th17 cell numbers in a nonlinear fashion. In smoking males, we found that UAs was associated with a significant decrease of Th17 cell numbers. Similar association was observed among non-smoking males. Likewise, UAs, DMA+3/+5 and MMA+3/+5 were associated with diminished production of IL-17A among non-smoking males. When stratified by Vitamin D levels defined as sufficient (≥20 ng/ml) and insufficient (<20 ng/ml), we found a substancial decrease in Th17 cell numbers among those with insufficient levels. Individuals with sufficient VitD levels demonstrated significant inhibition of IL-17A production in non-smoking males. Collectively, we find that exposure to As via drinking water is associated with alterations in Th17 numbers and IL-17A production, and that these associations may be modified by Vitamin D status. Our findings have significance for health outcomes associated with As exposure.

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“…A previous study showed that IL-13, the key regulator in type-2 mediated inflammation induces goblet cell hyperplasia to accelerate inflammation (Huang et al 2020). Arsenic has been linked to IL-13 induction (Rahman et al 2021), which could possibly lead to goblet cell hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway

Chakraborty

Gautam

Das

et al. 2022

Preprint

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This discourse attempts to capture a few important dimensions of gut physiology like microbial homeostasis, short chain fatty acid (SCFA) production, occludin expression and gut permeability in post-natal life of mice those received arsenic only during pre-natal life (pAs-mice). The pAs-mice showed a striking reduction in Firmicutes to Bacteroidetes (F/B) ratio coupled with decrease in tight junction protein, occludin resulting in increase in gut permeability, increased infiltration of inflammatory cells in the colon and decrease in common SCFAs in which butyrate reduction was quite prominent in fecal samples as compared to normal control. The above phenotypes of pAs-mice were mostly reversed by supplementing butyrate with food. The talismanic ability of butyrate in enhancing occludin expression, in particular, was dissected further. As miR122 causes degradation of Occludin mRNA, we transiently overexpressed miR122 by injecting appropriate plasmids and showed reversal of butyrate effects in pAs-mice. Thus, pre-natal arsenic exposure orchestrates variety of effects by decreasing in butyrate in pAs-mice leading to increased permeability due to reduced occludin expression. Our research adds a new dimension to our understanding that pre-natal arsenic exposure imprints in post-natal life while there was no further arsenic exposure.

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T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma

Cited by 20 publications

References 67 publications

Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway

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