T helper cell cytokine responses during intestinal nematode infection: induction, regulation and effector function.

Artis, David; Grencis, Richard K.; Kennedy, Malcolm W.; Harnett, William

doi:10.1079/9780851994239.0331

Cited by 19 publications

(16 citation statements)

References 143 publications

(174 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of a more generalized and sustained type 2 cytokine response may have been due to the rapid migration of A. suum larvae in the host or to the fact that regulation of these cytokines by T cells is dependent on different activation stimuli, kinetics, transcription factors, and cell types (37). Increased STAT6 gene expression in the pig ileum at 7 DAI is consistent with its role in murine intestinal responses to nematode infection (2,56,58), but STAT6 activity, like STAT4 activity in T. gondii-infected pigs, may be more a function of the state of phosphorylation than a function of gene expression (62).…”

Section: Discussionsupporting

confidence: 56%

“…in the intestine; these later stages are important in human morbidity and epidemiological studies. The protective immune response to Ascaris in pigs or humans is dominated by a Th2 response based on evidence of Ascaris-induced immunoglobulin E (IgE) production, peripheral eosinophilia, and increased ex vivo lymphocyte Th2 cytokine production (2,9,40). There is self-curing of fourth-stage larvae from the small intestine of swine between 2 and 3 weeks after inoculation that is associated with a localized mast cell-dependent immediatetype hypersensitivity response to parasite antigens (3,44).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Localized Multigene Expression Patterns Support an Evolving Th1/Th2-Like Paradigm in Response to Infections withToxoplasma gondiiandAscaris suum

et al. 2005

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 56%

mentioning

confidence: 99%

Localized Multigene Expression Patterns Support an Evolving Th1/Th2-Like Paradigm in Response to Infections withToxoplasma gondiiandAscaris suum

et al. 2005

View full text Add to dashboard Cite

“…Intestinal goblet cells, whose differentiation is controlled by Th2 cytokines (38,39), perform a number of functions, including secretion of mucins and other anti-microbial peptides. Indeed, goblet cells have been proposed as effector cells following infection with intestinal helminth parasites (39,49). Consistent with their ability to mount sufficient Th2 responses to clear T. muris infection, mice deficient in c-Rel had goblet cell responses equivalent to those of WT mice following infection.…”

Section: Susceptibility To T Muris Infection In Nf-b1 Ko and Nf-b2mentioning

confidence: 64%

Differential Requirement for NF-κB Family Members in Control of Helminth Infection and Intestinal Inflammation

Artis

Shapira

Mason

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

The NF-κB family of transcription factors is critical in controlling the expression of a wide range of immune response genes. However, whether individual family members perform specific roles in regulating immunity and inflammation remains unclear. Here we investigated the requirement for NF-κB1, NF-κB2, and c-Rel in the expression of Th2 cytokine responses, development of host protective immunity, and regulation of intestinal inflammation following infection with the gut-dwelling helminth parasite Trichuris muris. While mice deficient in c-Rel mounted sufficient Th2 responses to expel infection, NF-κB1 knockout (KO) and NF-κB2 KO mice developed chronic infections associated with elevated production of Ag-specific IFN-γ. However, only infected NF-κB1 KO mice exhibited polarized IFN-γ responses associated with the loss of intestinal goblet cells and the development of destructive colitis-like pathology. Furthermore, blockade of IL-12 (previously shown to confer resistance in susceptible strains) recovered Ag-specific IL-13 responses and resistance to infection in NF-κB2 KO, but not NF-κB1 KO mice. Therefore, unique infection, immunological, and pathological outcomes were observed in different NF-κB KO strains. Taken together, these results provide direct evidence of nonoverlapping functions for NF-κB family members in the development of Th2 cytokine-mediated resistance to T. muris and the control of infection-induced intestinal inflammation.

show abstract

“…The protective Th2-type responses required for resistance to T. muris are associated with intestinal goblet cell hyperplasia, an innate component of type 2 immunity at mucosal sites (22). In uninfected WT and WSX-1 Ϫ/Ϫ mice, numbers of intestinal goblet cells were similar (Fig.…”

Section: Enhanced Goblet Cell Responses In the Absence Of Wsx-1mentioning

confidence: 73%

The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity

Artis¹,

Villarino²,

Silverman

et al. 2004

The Journal of Immunology

223

210

View full text Add to dashboard Cite

Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1−/− mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.

show abstract

T helper cell cytokine responses during intestinal nematode infection: induction, regulation and effector function.

Abstract: Table 17.1. Mean worm burdens in IL-13 knockout (KO), IL-4 KO and wild-type mice at day 35 post-Trichuris muris infection.

Cited by 19 publications

References 143 publications

Localized Multigene Expression Patterns Support an Evolving Th1/Th2-Like Paradigm in Response to Infections withToxoplasma gondiiandAscaris suum

Localized Multigene Expression Patterns Support an Evolving Th1/Th2-Like Paradigm in Response to Infections withToxoplasma gondiiandAscaris suum

Differential Requirement for NF-κB Family Members in Control of Helminth Infection and Intestinal Inflammation

The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity

Contact Info

Product

Resources

About