T lymphocyte-mediated pyroptosis: A new regulatory mechanism in non-viral liver disease

Xiong, Wanyuan; Qian, Zibing; Mao, Xiaorong; Li, Junfeng

doi:10.1016/j.clinre.2022.102070

Cited by 1 publication

(1 citation statement)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Appropriate inflammatory response and induction of pyroptosis can enhance pathogen clearance. Pyroptosis also leads to the activation of the immune system, particularly helper T cell 1 (Th1) and helper T cell 2 (Th2) [ 80 ]. However, excessive pyroptosis can lead to a hyperinflammatory response and exacerbate tissue damage, which can lead to inflammatory diseases and immune disorders.…”

Section: Perspectivementioning

confidence: 99%

Bioactive Molecules against Rheumatoid Arthritis by Suppressing Pyroptosis

et al. 2023

View full text Add to dashboard Cite

Rheumatoid arthritis is an inflammatory disease, and pyroptosis is a form of death associated with an inflammatory response. Pyroptosis, which occurs in synovial and osteoblastic cells, can exacerbate the development of rheumatoid arthritis. The inhibition of pyroptosis of these cells can, therefore, clearly be used as a therapeutic strategy against rheumatoid arthritis. Here, we have summarized the current status of progress in the treatment of rheumatoid arthritis by targeting cellular pyroptosis. We have identified seven compounds, including a cyclic RNA, a microRNA, a peptide, and a cytokine (protein), that may influence the progression of rheumatoid arthritis by regulating the initiation of pyroptosis. All of these compounds have been shown to have anti-rheumatoid effects in vitro and/or in vivo and have the potential to be developed as anti-rheumatoid agents. These findings may help to accelerate the development of anti-rheumatoid arthritis drugs.

show abstract

Section: Perspectivementioning

confidence: 99%