T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling

Wang, Xinyi; Balaji, Swathi; Steen, Emily; Li, Hui; Rae, Meredith; Blum, Alan; Miao, Qi; Butte, Manish J.; Bollyky, Paul L.; Keswani, Sundeep G.

doi:10.1089/wound.2019.0981

Cited by 51 publications

(48 citation statements)

References 41 publications

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“…Figure 3 demonstrates how the reconstitution of lymphocytes, specifically CD4 + Th lymphocytes, prevents macrophage and neutrophil infiltration and collagen deposition, while increasing microvascular formation. The end result is less inflammation and fibrosis ( Wang et al, 2019 ). On the other hand, the adoptive transfer of B cells in animal models with chronic wounds accelerates wound closure, increases fibroblast infiltration and TGF-β1 expression, and decreases cell apoptosis within the wound space ( Sîrbulescu et al, 2017 ).…”

Section: Role Of Lymphocytes In Wound Healingmentioning

confidence: 99%

The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing

Singampalli

Balaji

Wang

et al. 2020

Front. Cell Dev. Biol.

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Scar formation is the typical endpoint of postnatal dermal wound healing, which affects more than 100 million individuals annually. Not only do scars cause a functional burden by reducing the biomechanical strength of skin at the site of injury, but they also significantly increase healthcare costs and impose psychosocial challenges. Though the mechanisms that dictate how dermal wounds heal are still not completely understood, they are regulated by extracellular matrix (ECM) remodeling, neovascularization, and inflammatory responses. The cytokine interleukin (IL)-10 has emerged as a key mediator of the pro- to anti-inflammatory transition that counters collagen deposition in scarring. In parallel, the high molecular weight (HMW) glycosaminoglycan hyaluronan (HA) is present in the ECM and acts in concert with IL-10 to block pro-inflammatory signals and attenuate fibrotic responses. Notably, high concentrations of both IL-10 and HMW HA are produced in early gestational fetal skin, which heals scarlessly. Since fibroblasts are responsible for collagen deposition, it is critical to determine how the concerted actions of IL-10 and HA drive their function to potentially control fibrogenesis. Beyond their independent actions, an auto-regulatory IL-10/HA axis may exist to modulate the magnitude of CD4 + effector T lymphocyte activation and enhance T regulatory cell function in order to reduce scarring. This review underscores the pathophysiological impact of the IL-10/HA axis as a multifaceted molecular mechanism to direct primary cell responders and regulators toward either regenerative dermal tissue repair or scarring.

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Section: Role Of Lymphocytes In Wound Healingmentioning

confidence: 99%

The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing

Singampalli

Balaji

Wang

et al. 2020

Front. Cell Dev. Biol.

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“…However, a series of standard procedures for PBMC collection, isolation, cryopreservation and preparation are crucial for their use in cell-based regenerative therapy[ 15 ]. PBMC contain terminally differentiated immune cells, namely monocytes and lymphocytes that also a play vital role in tissue remodeling and regeneration[ 19 - 21 ].…”

Section: Pbmc In Regenerationmentioning

confidence: 99%

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

Haque

Fareez

Fong

et al. 2020

WJSC

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In recent years, several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted cells. These findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor cells. Interestingly, this notion has also led scientists to question the role of proteins in the secretome produced by cells, tissues or organisms under certain conditions or at a particular time of regenerative therapy. Further studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected organs. This could also facilitate the migration of immune, progenitor and stem cells within the body to the site of inflammation. Of these different paracrine factors present within the secretome, researchers have given proper consideration to stromal cell-derived factor-1 (SDF1) that plays a vital role in tissue-specific migration of the cells needed for regeneration. Recently researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue regeneration. Hence in this study, we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.

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“…The first inflammatory response in the wound healing is recruitment of inflammatory cells such as neutrophils, macrophages, and lymphocytes. 17 Based on that finding, we need to confirm the profile of inflammatory cells responses in diabetic oral ulcer under treatment with LS-CE by histological assessment.…”

Section: Introductionmentioning

confidence: 98%

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

et al. 2020

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Objective The liquid smoke of coconut endocarp (LS-CE) contains high antioxidants that promote oral ulcer healing in diabetics. This study reveals the profile of inflammatory cell responses to oral ulcer healing in diabetics under treatment with LS-CE. Materials and Methods A diabetic model was induced with alloxan. Treatment with LS-CE was performed on oral ulcer at a dose of 1 μL/g weight for 3, 5, and 7 days. The anti-inflammatory effect was tested on animal’s oral ulcer model by measuring the inflammatory cell responses of the neutrophils, macrophages, lymphocytes, and fibroblasts through histological assessment. Results The LS-CE stimulated the healing by simultaneously increasing the inflammatory cell responses. The numbers of neutrophils, macrophages, and fibroblasts after treatment for 7 days are higher than that after 3 days and 5 days (p < 0.01), but not for neutrophils. The LS-CE shows increase in the fibroblasts by hastening responses of macrophage recruitment by five times, but not neutrophil and lymphocyte recruitment. The higher phenolic compounds in LS-CE are responsible for increase in the proliferation of fibroblasts, as it hastens cellular responses of macrophages. Conclusions The application of LS-CE enables hastening of the healing of diabetic oral ulcer by stimulating the macrophages.

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T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling

Cited by 51 publications

References 41 publications

The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing

The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

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