T Lymphocytes of Rheumatoid Arthritis Patients Show Augmented Reactivity to a Fraction of Mycobacteria Cross-Reactive With Cartilage

Holoshitz, Joseph; Klajman, A; Drucker, Ilana; Lapidot, Zvi; Yaretzky, A; Frenkel, A.; Eden, Willem van; Cohen, Irun R.

doi:10.1016/s0140-6736(86)90003-6

Cited by 265 publications

(101 citation statements)

References 27 publications

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“…There are already reports suggesting a disturbance in the lymphoproliferative [10], skin test [5], and antibody [4] responses to crude mycobacterial antigens in RA, Moreover, studies with monoclonal antibodies raised to mycobacterial antigen, but selected on rheumatoid synovial fluid, suggest that the human 65 kDa protein is abundant in inflamed joints (Sharif et al, unpublished observations).…”

Section: The Response To Mycobacterial Antigens In Ra and Other Diseamentioning

confidence: 99%

Rheumatoid Arthritis, Mycobacterial Antigens and Agalactosyl IgG

Rook¹

1988

Scand J Immunol

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Section: The Response To Mycobacterial Antigens In Ra and Other Diseamentioning

confidence: 99%

Rheumatoid Arthritis, Mycobacterial Antigens and Agalactosyl IgG

Rook¹

1988

Scand J Immunol

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“…[13][14][15][16] Microbial antigens, such as mycobacterial antigens and staphylococcal superantigens, may also contribute to T-cell activation in RA. 17,18 However, it is unclear whether T-cell responses to any of these antigens are clinically relevant to RA.…”

Section: Introductionmentioning

confidence: 99%

Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis

Sun

Nie²,

et al. 2005

Genes Immun

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T-lymphocytes play an important role in rheumatoid arthritis (RA). In this study, we evaluated the hypothesis that common T-cell receptor (TCR) structural features may exist among infiltrating T cells of different RA patients, if the TCR repertoire is shaped by interaction with common self or microbial antigens in the context of susceptible HLA genes in RA. Synovial lesion tissue (ST), synovial fluid (SF) and blood specimens from RA patients and controls were analyzed for TCR V gene repertoire by real-time PCR. There was highly skewed BV14 and BV16 usage in synovial T cells of RA as opposed to those of controls, which was accompanied with a trend for correlation between skewed BV16 and DRB1*0405. Immunoscope analysis of the V-D-J region of ST-derived T cells demonstrated oligoclonal and polyclonal expansion of BV14 þ and BV16 þ T cells. Detailed characterization using specific BV and BJ primers further revealed common clonotypes combining the same BV14/BV16, BJ and CDR3 length. DNA cloning and sequence analysis of the clonotypes confirmed identical CDR3 sequences and common CDR3 sequence motifs among different RA patients. The findings are important in the understanding of BV gene skewing and CDR3 structural characteristics among synovial infiltrating T cells of RA.

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“…In this case, the exaggerated reaction of SFL to PPD suggests that the cell-mediated immune response to M tuberciifosis was more vigorous inside the joint than in the circulation. Holoshitz and colleagues demonstrated antigenic similarity between a fraction of M tuberculosis and human cartilage ( 14). Those investigators also induced arthritis in rats, using a T lymphocyte clone that recognized both M tuberculosis antigens and antigens in human synovial fluid and cartilage (15).…”

mentioning

confidence: 99%

Tuberculous rheumatism (poncet's disease) in a child

Southwood

Hancock

Petty

et al. 1988

Arthritis & Rheumatism

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A 2‐year‐old boy who had increasing difficulty walking and had large, warm, sterile knee and ankle effusions was found to have active vertebral tuberculosis and a large prevertebral abscess. Lymphocyte proliferation assays demonstrated increased purified protein derivative‐induced reactivity of synovial fluid lymphocytes compared with peripheral blood lymphocytes. The arthritis responded rapidly to antituberculous and antiinflammatory drugs. This patient's disease represented an example of tuberculous rheumatism (Poncet's disease).

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T Lymphocytes of Rheumatoid Arthritis Patients Show Augmented Reactivity to a Fraction of Mycobacteria Cross-Reactive With Cartilage

Cited by 265 publications

References 27 publications

Rheumatoid Arthritis, Mycobacterial Antigens and Agalactosyl IgG

Rheumatoid Arthritis, Mycobacterial Antigens and Agalactosyl IgG

Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis

Tuberculous rheumatism (poncet's disease) in a child

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