T lymphopaenia in relation to body mass index and TNF‐α in human obesity: adequate weight reduction can be corrective

Tanaka, Shun‐ichi; Isoda, Fumiko; Ishihara, Yuri; Kimura, Mari; Yamakawa, Tadashi

doi:10.1046/j.1365-2265.2001.1139cn2155.x

Cited by 85 publications

(47 citation statements)

References 38 publications

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“…Obese patients after a moderate energy restriction have a lower mitogen-stimulated proliferation response and decreased monocyte oxidative burst as well as NK cell counts, but not T-and B-cell counts (Nieman et al, 1996). While total lymphocyte numbers did not change after a weight reduction program, the response of T-lymphocytes to different mitogens was increased as well as B-lymphocyte blastogenesis at the end of the dietary restriction period (Tanaka et al, 2001). During the slimming period, fasting blood glucose and serum triglyceride concentrations were slightly reduced.…”

Section: Obese Individuals and Immune Functionmentioning

confidence: 89%

Obesity and immunocompetence

2002

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The increasing worldwide prevalence of obesity is a major health problem since excessive body weight constitutes a risk factor in a number of chronic diseases. It has been reported that obese individuals are more susceptible to infection than lean subjects; however, the underlying factors are not fully understood. Limited and often controversial information exists comparing immunocompetence in obese and nonobese subjects as well as the cellular and molecular mechanisms involved, although much evidence supports a link between adipose tissue metabolism and immunocompetent cell functions. The complexity and heterogeneity of nutritional status and immune system interactions require an integral study of the immunocompetent cells, their subsets and products, as well as specific and non-specific inducer=regulatory systems in situations of human obesity. Additional research is needed to determine the clinical implications of these alterations on immunity and whether various interventions such as weight loss, exercise or nutrient supplementation could help to ameliorate them.

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Section: Obese Individuals and Immune Functionmentioning

confidence: 89%

Obesity and immunocompetence

2002

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“…Excess weight contributes to several health related complications which may include diabetes, cancers, kidney disease and hypertension [11]. It is indicated that obesity resulted in decreased immune counts and functions [22].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Malaria Parasite among Asymptomatic and Symptomatic Students of Federal University of Technology, Akure, Ondo State

Oke¹

2017

Br J Res

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This study was carried out to determine the prevalence of malaria parasites infection among asymptomatic and symptomatic students of the Federal University of Technology, Akure, Nigeria. A total of 300 students (150 each for the two categories of students), 155(51.67%) males and 145(48.33%) females; age range: <20-30 years were recruited for the study after informed consent. Both thick and thin films were made and stained using parasitological standard procedures after collection of blood samples from the students. Analysis of the result showed that 241(80.33%) of the subjects had malaria parasites, 80(53.3%) and 141(94.0%) prevalence for both categories respectively. Highest prevalence (59.0%) and (94.4%) was recorded among the males than the females (46.3%) and (93.6%) respectively for asymptomatic and symptomatic students. Age distribution showed the highest prevalence among subjects of age range <20 years in the two categories (68.4% and 100%) while the least prevalence of 42.9%, 76.9% and 48.3% were recorded among subjects of age range 25-27. According to Body index mass, the result showed that 55.0% of the infection occurred among underweight and 96.3% for normal weight for asymptomatic and symptomatic subjects with a significant difference (p=0.01). On the use of Insecticide Treated Net for both categories of students, those using nets had the higher prevalence of malaria infection 61.9% and 94.4% respectively. Asymptomatic malaria was a risk factor among the students therefore measures to reduce the prevalence are advocated.

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“…The power of NLR as an inflammatory factor stems from both a reduction in the lymphocyte count and an increase in the neutrophil count. Tanaka et al (30) showed that T lymphocytes were reduced in obese people and that lymphopenia appeared to be related to inflammation through TNFa. Neutrophils are the first immune cells to respond to inflammation and can exacerbate the chronic inflammatory state by helping recruit macrophages and by interacting with antigen-presenting cells.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Guo

Zhang

et al. 2015

European Journal of Endocrinology

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Aim: It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship between NLR and T2D. In order to evaluate how NLR is related to T2D, we designed a large-scale cross-sectional and prospective cohort study in an adult population. Subjects and methods: Participants were recruited from the Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (nZ87 686) and a prospective (nZ38 074) assessment were performed. Participants without a history of T2D were followed up for w6 years (with a median follow-up of 2.7 years). Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and T2D (covariates: age, sex, BMI, smoking status, drinking status, hypertension, hyperlipidemia, and family history of cardiovascular disease, hypertension, hyperlipidemia, or diabetes). Results: The prevalence and incidence of T2D were 4.9% and 6.8/1000 person-years respectively. The adjusted odds ratio and hazard ratio (95% CI) of the highest NLR quintile were 1.34 (1.21, 1.49) and 1.39 (1.09, 1.78) (both P for trend !0.01) respectively as compared to the lowest quintile of NLR. Leukocyte, neutrophil, and lymphocyte counts do not significantly predict the eventual development of T2D. Conclusion: The present study demonstrates that NLR is related to the prevalence and incidence of T2D, and it suggests that NLR may be an efficient and accurate prognostic biomarker for T2D.

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T lymphopaenia in relation to body mass index and TNF‐α in human obesity: adequate weight reduction can be corrective

Abstract: Our results suggest that subsets of T cell populations and their function may be reduced in human obesity, and that this may be related, at least in part, to the elevated TNF-alpha production. Furthermore, this T cell dysfunction can be recovered by adequate weight reduction.

Cited by 85 publications

References 38 publications

Obesity and immunocompetence

Obesity and immunocompetence

Prevalence of Malaria Parasite among Asymptomatic and Symptomatic Students of Federal University of Technology, Akure, Ondo State

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

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