T-Type Calcium Channels in Epilepsy

Sack, Anne-Sophie; Snutch, Terrance P.

doi:10.1007/978-3-031-08881-0_20

Voltage-Gated Calcium Channels 2022

DOI: 10.1007/978-3-031-08881-0_20

|View full text |Cite

T-Type Calcium Channels in Epilepsy

Anne-Sophie Sack

Terrance P. Snutch

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy

Waris,

Siraj,

Khan

et al. 2024

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

Epilepsy affects more than 70 million individuals of all ages worldwide and remains one of the most severe chronic noncommunicable neurological diseases globally. Several neurotransmitters, membrane protein channels, receptors, enzymes, and, more recently noted, various pathways, such as inflammatory and mTORC complexes, play significant roles in the initiation and propagation of seizures. Over the past two decades, significant developments have been made in the diagnosis and treatment of epilepsy. Various pharmacological drugs with diverse mechanisms of action and other treatment options have been developed to control seizures and treat epilepsy. These options include surgical treatment, nanomedicine, gene therapy, natural products, nervous stimulation, a ketogenic diet, gut microbiota, etc., which are in various developmental stages. Despite a plethora of drugs and other treatment options, one-third of affected individuals are resistant to current medications, while the majority of approved drugs have severe side effects, and significant changes can occur, such as pharmacoresistance, effects on cognition, long-term problems, drug interactions, risks of poor adherence, specific effects for certain medications, and psychological complications. Therefore, the development of new drugs and other treatment options that have no or minimal adverse effects is needed to combat this deadly disease. In this Review, we comprehensively summarize and explain all of the treatment options that have been approved or are in developmental stages for epilepsy as well as their status in clinical trials and advancements.

show abstract

A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy

Waris,

Siraj,

Khan

et al. 2024

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

T-Type Calcium Channels in Epilepsy

Cited by 1 publication

References 126 publications

A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy

A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy

Contact Info

Product

Resources

About