T1–T2 dual-modal MRI of brain gliomas using PEGylated Gd-doped iron oxide nanoparticles

Xiao, Ni; Gu, Wei; Wang, Hao; Deng, Yunlong; Shi, Xin; Ye, Ling

doi:10.1016/j.jcis.2013.11.020

Cited by 87 publications

(73 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The saturation magnetization of Fe 3 O 4 nanoparticles is measured to be~72 emu/g, whereas that of Gd-doped Fe 3 O 4 nanoparticles is reduced to~52 emu/g. This reduction in saturation magnetization at room temperature agrees with the observations in other reported studies [123,158] and can be attributed to the fact that magnetic Fe 3+ ions get replaced by the Gd 3+ ions in the octahedral sites of the inverse spinel structure. It is observed that the doping of Gd 3+ ions into Fe 3 O 4 spinel has significantly influenced the average crystallite size and the saturation magnetization.…”

Section: Gd-doped Spion As a Potential Theranostic Agentsupporting

confidence: 92%

“…For example, Zhou et al [122] have synthesized Gd 2 O 3 -embedded iron oxide nanoparticles with an overall size of 14 nm which can act as a T 1 -T 2 mutually enhanced dualmodal contrast agent for MR imaging of liver and hepatic tumor detection with great accuracy in mice. Xiao et al [123] have prepared PEGylated, Gd-doped iron oxide nanoparticles which is applicable as a T 1 -T 2 dual-modal MRI contrast agent. Their in vivo MRI results demonstrated the simultaneous contrast enhancements in T 1 -a n dT 2 -weighted MR images toward the gliomabearing mice.…”

Section: Spion For Cancer Diagnosis Using Mrimentioning

confidence: 99%

See 1 more Smart Citation

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Palihawadana-Arachchige¹,

Naik²,

Vaishnava³

et al. 2017

Nanostructured Materials - Fabrication to Applications

View full text Add to dashboard Cite

Nanotechnology has facilitated the applications of a class of nanomaterials called superparamagnetic iron oxide nanoparticles (SPIONs) in cancer theranostics. This is a new discipline in biomedicine that combines therapy and diagnosis in one platform. The multifunctional SPIONs, which are capable of detecting, visualizing, and destroying the neoplastic cells with fewer side effects than the conventional therapies, are reviewed in this chapter for theranostic applications. The chapter summarizes the design parameters such as size, shape, coating, and target ligand functionalization of SPIONs, which enhance their ability to diagnose and treat cancer. The review discusses the methods of synthesizing SPIONs, their structural, morphological, and magnetic properties that are important for theranostics. The applications of SPIONs for drug delivery, magnetic resonance imaging, and magnetic hyperthermia therapy (MHT) are included. The results of our recent MHT study on Gd-doped SPION as a possible theranostic agent are highlighted. We have also discussed the challenges and outlook on the future research for theranostics in clinical settings.

show abstract

Section: Gd-doped Spion As a Potential Theranostic Agentsupporting

confidence: 92%

Section: Spion For Cancer Diagnosis Using Mrimentioning

confidence: 99%

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Palihawadana-Arachchige¹,

Naik²,

Vaishnava³

et al. 2017

Nanostructured Materials - Fabrication to Applications

View full text Add to dashboard Cite

show abstract

“…Therefore, those peaks of standard Gd 2 O 3 were reported at 1,188 eV and 1,220 eV. 27 Such a subtle shift of the …”

Section: Yao Et Almentioning

confidence: 99%

Construction of magnetic-carbon-quantum-dots-probe-labeled apoferritin nanocages for bioimaging and targeted therapy

Yao¹,

Su²,

Zeng³

et al. 2016

IJN

View full text Add to dashboard Cite

Carbon dots (CDs) are one of the most highlighted carbon-based materials for biological applications, such as optical imaging nanoprobes, which are used for labeling cells in cancer treatment mainly due to their biocompatibility and unique optical properties. In this study, gadolinium (Gd)-complex-containing CDs were obtained through a one-step microwave method to develop multimodal nanoprobes integrating the advantages of optical and magnetic imaging. The obtained Gd-CDs exhibited highly fluorescent properties with excellent water solubility and biological compatibility. Natural apoferritin (AFn) nanocages, an excellent drug delivery carrier, are hollow in structure, with their pH-dependent, unfolding–refolding process at pH 2.0 and 7.4. The chemotherapeutic drug doxorubicin (DOX) can be highly effective and encapsulated into AFn cavity. A widely used tumor-targeting molecule, folic acid (FA), functionalized the surface of AFn to obtain an active tumor targeting effect on MCF-7 cells and malignant tumors in mice models. In this study, an AFn nanocarrier encapsulating high concentration of DOX labeled with magnetic and fluorescent Gd-CDs probe was developed. Gd-CDs exhibited a unique green photoluminescence and almost no toxicity compared with free GdCl 3 . Furthermore, Gd-doped CDs significantly increased the circulation time and decreased the toxicity of Gd 3+ in in vitro and in vivo magnetic resonance imaging, which demonstrated that the AFn nanocages labeled with Gd-CD compounds could serve as an excellent T 1 contrast agent for magnetic resonance imaging. The self-assembling multifunctional Gd-CDs/AFn (DOX)/FA nanoparticles have a great potential for cancer theranostic applications.

show abstract

“…This might be due to easier proton exchange between the bulk water and the Gd in NTLs and GTLs. 25,46 Confocal microscopy and flow cytometry analysis studies…”

Section: Synthesis and Characterization Of Liposomal Materials And Fomentioning

confidence: 99%

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

Gu¹,

Li²,

Zhang³

et al. 2015

IJN

View full text Add to dashboard Cite

Novel gadolinium-loaded liposomes guided by GBI-10 aptamer were developed and evaluated in vitro to enhance magnetic resonance imaging (MRI) diagnosis of tumor. Nontargeted gadolinium-loaded liposomes were achieved by incorporating amphipathic material, Gd (III) [ N , N -bis-stearylamidomethyl- N ′-amidomethyl] diethylenetriamine tetraacetic acid, into the liposome membrane using lipid film hydration method. GBI-10, as the targeting ligand, was then conjugated onto the liposome surface to get GBI-10-targeted gadolinium-loaded liposomes (GTLs). Both nontargeted gadolinium-loaded liposomes and GTLs displayed good dispersion stability, optimal size, and zeta potential for tumor targeting, as well as favorable imaging properties with enhanced relaxivity compared with a commercial MRI contrast agent (CA), gadopentetate dimeglumine. The use of GBI-10 aptamer in this liposomal system was intended to result in increased accumulation of gadolinium at the periphery of C6 glioma cells, where the targeting extracellular matrix protein tenascin-C is overexpressed. Increased cellular binding of GTLs to C6 cells was confirmed by confocal microscopy, flow cytometry, and MRI, demonstrating the promise of this novel delivery system as a carrier of MRI contrast agent for the diagnosis of tumor. These studies provide a new strategy furthering the development of nanomedicine for both diagnosis and therapy of tumor.

show abstract

T1–T2 dual-modal MRI of brain gliomas using PEGylated Gd-doped iron oxide nanoparticles

Cited by 87 publications

References 28 publications

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Construction of magnetic-carbon-quantum-dots-probe-labeled apoferritin nanocages for bioimaging and targeted therapy

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

Contact Info

Product

Resources

About

T1–T2 dual-modal MRI of brain gliomas using PEGylated Gd-doped iron oxide nanoparticles

Cited by 87 publications

References 28 publications

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Construction of magnetic-carbon-quantum-dots-probe-labeled apoferritin nanocages for bioimaging and targeted therapy

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by&nbsp;magnetic resonance imaging

Contact Info

Product

Resources

About

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging