T1302 Moderately Severe Acute Pancreatitis: A Prospective Validation Study of This New Subgroup of Acute Pancreatitis

Talukdar, Rupjyoti; Vege, Santhi Swaroop; Chari, Suresh T.; Clemens, Magdalen A.; Pearson, Randall K.

doi:10.1016/s0016-5085(09)62497-5

Cited by 20 publications

(31 citation statements)

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“…Although previously reported by Nadkarni et al 13 , our study did not find a relationship between AP mortality and QTc-interval prolongation, pericardial effusion, and 13 and the known risk of mortality with higher AP severity 16,17 , the lack of significance may be secondary to our sample size. Two of these patients had a follow-up EKG and did not have QTc-interval prolongation, ruling out its presence due to an unknown underlying primary cardiac condition.…”

Section: Discussioncontrasting

confidence: 85%

“…Not all testing was performed simultaneously. For this reason, the ACFs described may represent different stages of a disease known for its dynamism 16,17 . However, as shown by the median time to each type of study, most studies (52%) were performed within the first 3 days of disease progression.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the fact that both moderately severe and severe APs have a worse prognosis than mild AP 16,17 , we classified AP as mild or moderate/severe to increase the sensitivity of the study.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Abnormal Cardiovascular Findings in Acute Pancreatitis: Are They Associated with Disease Severity?

Chacón-Portillo

Payro-Ramírez

Peláez-Luna

et al. 2017

RIC

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Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Abnormal Cardiovascular Findings in Acute Pancreatitis: Are They Associated with Disease Severity?

Chacón-Portillo

Payro-Ramírez

Peláez-Luna

et al. 2017

RIC

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“…Dauguma šios grupės pacientų gali pasveikti per 2-3 savaites be didesnių chirurginių intervencijų, o mirtingumas yra kur kas mažesnis nei sergant sunkiu ŪP [9,14,15].…”

Section: Atlantos Klasifikacijaunclassified

Pirmieji multicentrinės perspektyvinės studijos „uždegimo žymenų reikšmė skubiam ūminio pankreatito sunkumo įvertinimui“ rezultatai

Karpavičius¹,

Šileikis²,

Gradauskas

et al. 2015

Medicinos Teorija Ir Praktika

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Reikšminiai žodžiai: ūminis pankreatitas, prognozavimas, C-reaktyvus baltymas, hematokritas. Darbo tikslas. Nustatyti CRB ir hematokrito prognostines galimybes, prognozuojant ūminio pankreatito eigą. Medžiaga ir metodai. Multicentrinė perspektyvinė studija buvo vykdoma keturiose Vilniaus ir Kauno gydymo įstaigose. Tirtas ūminiu pankreatitu sirgusių pacientų kraujo serumas 1-ą ir 3-ią hospitalizacijos parą, siekiant nustatyti CRB ir hematokrito vertes. Remiantis atnaujintu Atlantos sutarimu, visi pacientai buvo suskirstyti į tris grupes pagal ligos eigą: lengvo, vidutinio sunkumo ir sunkaus ūminio pankreatito. CRB ir hematokrito vertės lygintos tarp grupių, ir, braižant ROC kreives, nustatytos kritinės reikšmės, kuriomis remiantis galima prognozuoti sunkios eigos ūminį pankreatitą. Rezultatai. Tyrime dalyvavo 102 ūminiu pankreatitu sirgę pacientai. Iš jų lengvu ūminiu pankreatitu sirgo 27 (26,5 proc.), vidutinio sunkumo – 55 (53,9 proc.) ir sunkiu – 20 (19,6 proc.) asmenų. Nustatyta, jog kritinė CRB reikšmė, statistiškai patikimai atskirianti sunkų ūminį pankreatitą nuo lengvo bei vidutinio sunkumo, trečią hospitalizacijos parą yra 301,1 mg/l (jautrumas 70,7 proc., specifiškumas 80 proc., AUC 0,79). Pirmą hospitalizacijos parą sunkios eigos pankreatitą patikimai atskiria ribinė 44,3 proc. hematokrito vertė (jautrumas 68,3 proc., specifiškumas 85 proc., AUC 0,77). Išvados. Hematokritas yra gana ankstyvas ir tikslus žymuo, diferencijuojantis sunkų ūminį pankreatitą nuo lengvo bei vidutinio sunkumo. CRB ankstyvam prognozavimui nelabai tinka, nes geriausiomis prognostinėmis savybėmis pasižymi praėjus kelioms paroms nuo susirgimo pradžios.

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“…The process was repeated and a third draft was generated, which contained minor modifications. After this, the final revision was made wherein the three-tier classification of severity was incorporated (27,33).…”

Section: Genesismentioning

confidence: 99%

Classification Systems for the Severity of Acute Pancreatitis

Talukdar¹

The Pancreapedia: Exocrine Pancreas Knowledge Base

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Abstract:The quest for a clinically relevant severity classification system for acute pancreatitis (AP) is still ongoing. Several systems have been proposed since 1889, including the Marseilles, Cambridge and Marseilles-Rome classifications. In 1993, the Atlanta Classification was published which was widely used in patient care and clinical research. Eventually, several confusions and lack of clarity were observed in this classification. At the same time, there was increasing understanding of the pathophysiology of AP and several new terminologies emerged. This resulted in the development of the Revised Atlanta Classification though a web based multiply iterative process. The Revised Atlanta Classification has introduced a three-tier severity system, with the moderately severe AP being the new group. This classification also describes necrosis, organ failure and local complications with more clarity. Concomitantly, another four-tier severity classification of AP was introduced, which categorizes severity based on the actual determinants of mortality, i.e. infected necrosis and organ failure. This classification introduces a fourth category namely critical acute pancreatitis.In this chapter, we elaborate on the Atlanta, Revised Atlanta and the Determinant based classification systems, and discuss their relevance, utility and limitations.

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T1302 Moderately Severe Acute Pancreatitis: A Prospective Validation Study of This New Subgroup of Acute Pancreatitis

Cited by 20 publications

References 0 publications

Abnormal Cardiovascular Findings in Acute Pancreatitis: Are They Associated with Disease Severity?

Abnormal Cardiovascular Findings in Acute Pancreatitis: Are They Associated with Disease Severity?

Pirmieji multicentrinės perspektyvinės studijos „uždegimo žymenų reikšmė skubiam ūminio pankreatito sunkumo įvertinimui“ rezultatai

Classification Systems for the Severity of Acute Pancreatitis

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