T1303 Prevention of NSAID-Induced Small Intestinal Injury By Prostaglandin: A Pilot Randomized Controlled Trial

Distribution of small intestinal mucosal injuries as a result of NSAID administration

“…This study expands on the work of two recent studies by authors on the prevention of NSAID-induced small intestinal injury by prostaglandin and rebamipide [9,10]. Control subjects from those two studies, on NSAID and proton-pump inhibitor medication, but neither on prostaglandin nor on rebamipide therapy, were further analysed for extent and location of small intestinal injury.…”

“…Capsule endoscopy and double‐balloon endoscopy, advanced modalities that now allow for full investigation of the entire small intestine, have revealed that NSAIDs can cause a variety of abnormalities in the small intestine; including ulcerations, perforations, bleeding and diaphragm‐like strictures [4–6]. Capsule endoscopy studies have shown that NSAIDs co‐administrated with proton‐pump inhibitors cause small intestinal damage in up to 60% of healthy volunteers [7–9]. Our own capsule endoscopy study has shown that co‐administration of misoprostol or rebamipide partially prevented NSAID‐induced small intestinal damage [9,10].…”

“…Capsule endoscopy studies have shown that NSAIDs co‐administrated with proton‐pump inhibitors cause small intestinal damage in up to 60% of healthy volunteers [7–9]. Our own capsule endoscopy study has shown that co‐administration of misoprostol or rebamipide partially prevented NSAID‐induced small intestinal damage [9,10]. In addition, studies have shown that luminal factors such as bacteria and bile acids might also interact with NSAIDs to cause small intestinal injury [11].…”