T1ρ is superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis: Radiological–pathological correlation after total knee arthroplasty

Takayama, Yoshiaki; Hatakenaka, Masamitsu; Tsushima, Hiroyuki; Okazaki, Ken; Yamada, Takashi; Yonezawa, Masato; Nishikawa, Kei; Iwamoto, Yukihide; Honda, Hiroshi

doi:10.1016/j.ejrad.2012.11.031

Cited by 37 publications

(28 citation statements)

References 25 publications

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“…31 This is attributed to its higher dynamic range and sensitivity to early changes. 45,53 On the other hand, T2 is a more widely available technique and has also been used in the OAI data sets. 57 In our study, we observed that 2 of the T1rho parameters and 1 of the T2 parameters were significantly higher in the OA group, suggesting greater sensitivity of the T1rho metric.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

Kumar

Souza

Singh

et al. 2014

J Orthop Sports Phys Ther

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STUDY DESIGN Cross-sectional. OBJECTIVES To investigate the association between knee loading–related osteoarthritis (OA) risk factors (obesity, malalignment, and physical activity) and medial knee laminar (superficial and deep) T1rho and T2 relaxation times. BACKGROUND The interaction of various modifiable loading-related knee risk factors and cartilage health in knee OA is currently not well known. METHODS Participants with and without knee OA (n = 151) underwent magnetic resonance imaging at 3 T for superficial and deep cartilage T1rho and T2 magnetic resonance relaxation times in the medial femur (MF) and medial tibia (MT). Other variables included radiographic Kellgren-Lawrence (KL) grade, alignment, pain and symptoms using the Knee injury and Osteoarthritis Outcome Score, and physical activity using the International Physical Activity Questionnaire (IPAQ). Individuals with a KL grade of 4 were excluded. Group differences were calculated using 1-way analysis of variance, adjusting for age and body mass index. Linear regression models were created with age, sex, body mass index, alignment, KL grade, and the IPAQ scores to predict the laminar T1rho and T2 times. RESULTS Total IPAQ scores were the only significant predictors among the loading-related variables for superficial MF T1rho (P = .005), deep MT T1rho (P = .026), and superficial MF T2 (P = .049). Additionally, the KL grade predicted the superficial MF T1rho (P = .023) and deep MT T1rho (P = .022). CONCLUSION Higher physical activity levels and worse radiographic severity of knee OA, but not obesity or alignment, were associated with worse cartilage composition.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

Kumar

Souza

Singh

et al. 2014

J Orthop Sports Phys Ther

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“…Quantitative T 1ρ relaxation time measurements are promising biomarkers for evaluation of preventive surgery and for knee repair surgery, which addresses traumatic or degenerative pathologies . T 1ρ mapping may also be used in postoperative imaging for outcome evaluation of different surgical procedures as well as individual outcome analysis and prediction, and early detection of degenerative changes before distinct morphological changes occur, although only a small number of studies have peen performed to date using T 1ρ imaging for evaluation of knee repair procedures . Figure shows representative T 1ρ and T 2 maps 3–6 months and 1 year after mosaicplasty (MOS) surgery, respectively.…”

Section: T1ρ Imaging Of the Knee Jointmentioning

confidence: 99%

“…T 1ρ ‐weighted imaging has been extensively used in the past decades to assess pathology of liver, muscle, breast, brain, and tumor besides those of human MSK system . These studies have demonstrated the potential values of T 1ρ imaging for evaluating various physiologic and pathologic states.…”

Section: Future Prospectsmentioning

confidence: 99%

T_1ρ MRI of human musculoskeletal system

Wang

Regatte

2014

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) offers the direct visualization of human musculoskeletal (MSK) system, especially all diarthrodial tissues including cartilage, bone, menisci, ligaments, tendon, hip, synovium etc. Conventional MR imaging techniques based on T1- and T2-weighted, proton density (PD) contrast are inconclusive in quantifying early biochemically degenerative changes in MSK system in general and articular cartilage in particular. In recent years, quantitative MR parameter mapping techniques have been used to quantify the biochemical changes in articular cartilage with a special emphasis on evaluating joint injury, cartilage degeneration, and soft tissue repair. In this article, we will focus on cartilage biochemical composition, basic principles of T1ρ MR imaging, implementation of T1ρ pulse sequences, biochemical validation, and summarize the potential applications of T1ρ MR imaging technique in MSK diseases including osteoarthritis (OA), anterior cruciate ligament (ACL) injury, and knee joint repair. Finally, we will also review the potential advantages, challenges, and future prospects of T1ρ MR imaging for widespread clinical translation.

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“…Other known quantitative MRI techniques include delayed gadoliniumenhanced MRI in cartilage (dGEMRIC) [6] and T2 relaxation time quantification [7]. The T1 technique requires no contrast agent, unlike dGEMRIC, and it is considered to be more powerful than T2 imaging for evaluating the degeneration of articular cartilage [8]. Therefore, the T1 mapping technique may be a pre-structural indicator of osteoarthritis [9].…”

Section: Introductionmentioning

confidence: 98%

Medial meniscal posterior root/horn radial tears correlate with cartilage degeneration detected by T1ρ relaxation mapping

Takahashi

Hashimoto²,

Nakamura

et al. 2015

European Journal of Radiology

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T1ρ is superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis: Radiological–pathological correlation after total knee arthroplasty

Cited by 37 publications

References 25 publications

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

T_1ρ MRI of human musculoskeletal system

Medial meniscal posterior root/horn radial tears correlate with cartilage degeneration detected by T1ρ relaxation mapping

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T1ρ is superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis: Radiological–pathological correlation after total knee arthroplasty

Cited by 37 publications

References 25 publications

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

T1ρ MRI of human musculoskeletal system

Medial meniscal posterior root/horn radial tears correlate with cartilage degeneration detected by T1ρ relaxation mapping

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T_1ρ MRI of human musculoskeletal system