2020
DOI: 10.3390/ijerph17030708
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T1ρ-Mapping for Musculoskeletal Pain Diagnosis: Case Series of Variation of Water Bound Glycosaminoglycans Quantification before and after Fascial Manipulation® in Subjects with Elbow Pain

Abstract: Diagnosis and management of musculoskeletal pain is a major clinical challenge. Following this need, the first aim of our study was to provide an innovative magnetic resonance technique called T1ρ to quantify possible alterations in elbow pain, a common musculoskeletal pain syndrome that has not a clear etiology. Five patients were recruited presenting chronic elbow pain (>3 months), with an age between 30 and 70 years old. Patients underwent two T1ρ-mapping evaluations, one before and one after the series … Show more

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Cited by 24 publications
(19 citation statements)
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“…HA is considered a lubricant that allows the gliding i.e., between individual layers of the deep fascia, and its high concentration can increase the viscosity in the extracellular matrix (ECM) of the FT, generating pain. Results shows that FM seems to hydrolyze the overflow amount of self-aggregate GAG/HA reducing the viscoelasticity of the ECM in the affected elbow regions after treatment (Menon et al, 2020). It is also proposed that SI may have an effect on myofascial adhesions, which could theoretically increase blood perfusion (Portillo-Soto et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…HA is considered a lubricant that allows the gliding i.e., between individual layers of the deep fascia, and its high concentration can increase the viscosity in the extracellular matrix (ECM) of the FT, generating pain. Results shows that FM seems to hydrolyze the overflow amount of self-aggregate GAG/HA reducing the viscoelasticity of the ECM in the affected elbow regions after treatment (Menon et al, 2020). It is also proposed that SI may have an effect on myofascial adhesions, which could theoretically increase blood perfusion (Portillo-Soto et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, myofascial techniques used in SI may influence the ground substance of the soft tissues and mechanoreceptors, contributing to decreased excessive muscle tension, changes in local fluid dynamics, capillary constriction, and improved local blood perfusion ( Schleip, 2003a , b ). Moreover, changes in fluid dynamics could be explained by the last study of Menon et al (2020) , which using proton T1ρ relaxation mapping to determine intramuscular glycosaminoglycan (GAG) content. Their data suggest that the application of the fascial manipulation (FM) method seems to decrease the concentration of unbound water inside the deep fascia in the patients with chronic elbow pain and stimulate to produce the correct quality and quantity of hyaluronan (HA).…”
Section: Discussionmentioning
confidence: 99%
“…The results obtained by all authors can be explained by this non-standard approach to the patient in FM® technique that is based on looking for causes of symptoms. An ability to find an altered deep fascial region and mechanisms of pain can make therapies more effective than treating only symptomatic part of the body (5). The deep fascia consists of layers of dense connective tissue which transmit the load and loose connective tissue that allows gliding of the collagen layers (13).…”
Section: Discussionmentioning
confidence: 99%
“…They are able to transmit forces and also to cause pain -due to free nerves endings and receptors within the fascia. Fascia can also cause restriction of motion of the organs as a result of an injury, inflammation or infection (4)(5)(6).…”
Section: Introductionmentioning
confidence: 99%
“…Pain syndromes may be related to increased thickness of the deep fascia [ 17 ] corresponding to an increase and change in extracellular matrix [ 18 , 19 ]. This aggregation of extracellular matrix in the deep fascia is termed densification [ 20 ].…”
Section: Introductionmentioning
confidence: 99%