T2-hyperintensity of the Middle Cerebellar Peduncles in a Patient with SCA7

Yoshida, Shun; Kikuchi, Akio; Tateyama, Masao; Akiyama, Masashi

doi:10.2169/internalmedicine.52.0302

Cited by 2 publications

(1 citation statement)

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“…On MRI, atrophy of the cerebellum and pons, and T2 hyperintensity of the middle cerebellar peduncles is occasionally observed (Fig. 7 ) [ 42 , 43 ]. The hot cross bun sign is rare in patients with SCA7 [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and neuroimaging review of triplet repeat diseases

Kurokawa

Mitsutake

et al. 2022

Jpn J Radiol

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Triplet repeat diseases (TRDs) refer to a group of diseases caused by three nucleotide repeats elongated beyond a pathologic threshold. TRDs are divided into the following four groups depending on the pathomechanisms, although the pathomechanisms of several diseases remain unelucidated: polyglutamine disorders, caused by a pathologic repeat expansion of CAG (coding the amino acid glutamine) located within the exon; loss-of-function repeat disorders, characterized by the common feature of a loss of function of the gene within which they occur; RNA gain-of-function disorders, involving the production of a toxic RNA species; and polyalanine disorders, caused by a pathologic repeat expansion of GCN (coding the amino acid alanine) located within the exon. Many of these TRDs manifest through neurologic symptoms; moreover, neuroimaging, especially brain magnetic resonance imaging, plays a pivotal role in the detection of abnormalities, differentiation, and management of TRDs. In this article, we reviewed the clinical and neuroimaging features of TRDs. An early diagnosis of TRDs through clinical and imaging approaches is important and may contribute to appropriate medical intervention for patients and their families.

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Section: Introductionmentioning

confidence: 99%