T2 mapping in dermatomyositis/polymyositis and correlation with clinical parameters

Ran, Jun; Ji, Suqiong; Morelli, John N.; Wu, Gang; Li, X.

doi:10.1016/j.crad.2018.07.106

Cited by 21 publications

(16 citation statements)

References 22 publications

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“…This suggests that these measures may be a useful non-invasive measure in the diagnosis and monitoring of myositis. This is corroborated by the ROC analysis area AUC values which, despite not being adequately powered, demonstrate that T2 and FF could be useful in the diagnosis of myositis, in particular T2, which is sensitive to both oedema and fatty infiltration, supporting previous work by Ran et al 12 T2 was higher in myositis patients compared to healthy controls, which is consistent with previous studies. 10,29 This may be due to the combined effects of increased fat (10,43), inadequately suppressed by the SPAIR fat suppression, and increased fluid due to inflammation.…”

Section: Discussionsupporting

confidence: 91%

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

et al. 2021

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imaging (MRI)-based measurements of T2, fat fraction, diffusion tensor imaging, and muscle volume can detect differences between the muscles of myositis patients and healthy controls, and to identify how they compare with semi-quantitative MRI diagnosis. MATERIALS AND METHODS: Sixteen myositis patients and 16 age-and gender-matched healthy controls underwent MRI of their thigh. Quantitative MRI measurements and radiologists' semi-quantitative scores were assessed. Strength was assessed using an isokinetic dynamometer. RESULTS: Fat fraction and T2 values were higher in myositis patients whereas muscle volume was lower compared to healthy controls. There was no difference in diffusion. Muscle strength was lower in myositis patients compared to healthy controls. In a subgroup of eight patients, scored as unaffected by radiologists, T2 values were still significantly higher in myositis patients. CONCLUSIONS: Quantitative MRI measurements can detect differences between myositis patients and healthy controls. Changes in the muscles of myositis patients, undetected by visual, semi-quantitative scoring, can be detected using quantitative T2 measurements. This suggests that MRI T2 values may be useful for the management of myositis patients.

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Section: Discussionsupporting

confidence: 91%

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

et al. 2021

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“…Furthermore, nearly all pathophysiological changes can cause T2‐relaxation changes. These comprise also fiber necrosis and cell swelling 18 . Edema and necrosis can be interpreted as signs of acute disease.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been shown that also EMG findings can quantitatively reflect muscle alteration 13 . However, the EMG signal might only display a small area of the muscle surrounding the inserted needle and not the muscle as a whole 18 . Typical EMG findings in myositis patients are PSA comprising, for example, fibrillations, positive sharp waves, and myotonic discharges 13 .…”

Section: Discussionmentioning

confidence: 99%

“…In acute disease stages with inflammation, a loss of myofibrils leads to MUPs small in amplitude, short in duration, and polyphasic 13 . It is a known fact that EMG correlates with the clinical presentation in myopathy patients 13,18,19 . However, the exact underlying tissue alterations causing these phenomena are still unclear, which can be also be stated for MRI 18 .…”

Section: Discussionmentioning

confidence: 99%

“…It is a known fact that EMG correlates with the clinical presentation in myopathy patients 13,18,19 . However, the exact underlying tissue alterations causing these phenomena are still unclear, which can be also be stated for MRI 18 . However, there are first reports that EMG findings well correlate with histopathology 20 …”

Section: Discussionmentioning

confidence: 99%

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Associations between magnetic resonance imaging and EMG findings in myopathies

Meyer¹,

Schneider

Emmer

et al. 2020

Acta Neurol Scand

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MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment?

et al. 2020

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Objectives To assess the ability of quantitative T2, diffusion tensor imaging (DTI) and radiologist’s scores to detect muscle changes following acute muscle tear in soccer and rugby players. To assess the ability of these parameters to predict return to play times. Methods In this prospective, longitudinal study, 13 male athletes (age 19 to 34 years; mean 25 years) underwent MRI within 1 week of suffering acute muscle tear. Imaging included measurements of T2 and DTI parameters. Images were also assessed using modified Peetrons and British athletics muscle injury classification (BAMIC) scores. Participants returned for a second scan within 1 week of being determined fit to return to play. MRI measurements were compared between visits. Pearson’s correlation between visit 1 measurements and return to play times was assessed. Results There were significant differences between visits in BAMIC scores (Z = − 2.088; p = 0.037), modified Peetrons (Z = − 2.530; p = 0.011) and quantitative MRI measurements; T2, 13.12 ms (95% CI, 4.82 ms, 21.42 ms; p = 0.01); mean diffusivity (0.22 (0.04, 0.39); p = 0.02) and fractional anisotropy (0.07 (0.01, 0.14); p = 0.03). BAMIC scores showed a significant correlation with return to play time (Rs = 0.64; p = 0.02), but modified Peetrons scores and quantitative parameters did not. Conclusions T2 and DTI measurements in muscle can detect changes due to healing following muscle tear. Although BAMIC scores correlated well with return to play times, in this small study, quantitative MRI values did not, suggesting that T2 and DTI measurements are inferior predictors of return to play time compared with visual scoring. Key Points • Muscle changes following acute muscle tear can be measured using T2 and diffusion measurements on MRI. • Measurements of T2 and diffusion using MRI are not as good as a radiologist’s visual report at predicting return to play time after acute muscle tear.

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T2 mapping in dermatomyositis/polymyositis and correlation with clinical parameters

Cited by 21 publications

References 22 publications

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

Associations between magnetic resonance imaging and EMG findings in myopathies

MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment?

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