T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression

Sollmann, Nico; Weidlich, Dominik; Klupp, Elisabeth; Cervantes, Barbara; Ganter, Carl; Zimmer, Claus; Rummeny, Ernst J.; Baum, Thomas; Kirschke, Jan S.; Karampinos, Dimitrios C.

doi:10.1007/s10334-020-00832-w

Cited by 12 publications

(10 citation statements)

References 47 publications

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“…With regard to peripheral nerve MTI, we are aware of two previous studies that have assessed reliability in smaller cohorts (Yiannakas et al [28]: 5 participants, ICC interreader 0.65, ICC test-retest 0.76; Dortch et al [11]: 13 participants, ICC interreader 0.92, ICC test-retest 0.69), although the main focus of these studies was on other research concerns [11,28]. Regarding T2 relaxometry, Sollmann et al [29] have recently reported promising first results for interreader reliability while test-retest reliability had not been assessed yet to our knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…For T2 of the sciatic nerve, the present study implies an MDD of approximately 7.4 ms. For comparison, previously reported significant differences of T2 ranged from 10.8 to 26.6 ms between patients and control groups (Table 5 ) [ 13 , 25 , 29 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…To use these parameters for decisions in individual patients, it is crucial to assess reliability by a quantitative estimation of the measurement error attributed to different examinations (test-retest) or different readers (interreader). First studies implemented reliability analyses of these techniques in their investigations with promising results, but a systematic assessment of both test-retest and interreader reliability in a larger cohort and a quantification of the measurement error are still lacking [ 11 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry

et al. 2021

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Objectives To assess the interreader and test-retest reliability of magnetization transfer imaging (MTI) and T2 relaxometry in sciatic nerve MR neurography (MRN). Materials and methods In this prospective study, 21 healthy volunteers were examined three times on separate days by a standardized MRN protocol at 3 Tesla, consisting of an MTI sequence, a multi-echo T2 relaxometry sequence, and a high-resolution T2-weighted sequence. Magnetization transfer ratio (MTR), T2 relaxation time, and proton spin density (PSD) of the sciatic nerve were assessed by two independent observers, and both interreader and test-retest reliability for all readout parameters were reported by intraclass correlation coefficients (ICCs) and standard error of measurement (SEM). Results For the sciatic nerve, overall mean ± standard deviation MTR was 26.75 ± 3.5%, T2 was 64.54 ± 8.2 ms, and PSD was 340.93 ± 78.8. ICCs ranged between 0.81 (MTR) and 0.94 (PSD) for interreader reliability and between 0.75 (MTR) and 0.94 (PSD) for test-retest reliability. SEM for interreader reliability was 1.7% for MTR, 2.67 ms for T2, and 21.3 for PSD. SEM for test-retest reliability was 1.7% for MTR, 2.66 ms for T2, and 20.1 for PSD. Conclusions MTI and T2 relaxometry of the sciatic nerve are reliable and reproducible. The values of measurement imprecision reported here may serve as a guide for correct interpretation of quantitative MRN biomarkers in future studies. Key Points • Magnetization transfer imaging (MTI) and T2 relaxometry of the sciatic nerve are reliable and reproducible. • The imprecision that is unavoidably associated with different scans or different readers can be estimated by the here presented SEM values for the biomarkers T2, PSD, and MTR. • These values may serve as a guide for correct interpretation of quantitative MRN biomarkers in future studies and possible clinical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry

et al. 2021

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“…These studies showed higher T2 relaxation values in compressive neuropathy compared with normal nerves, emphasizing the potential role of this technique as an objective and reproducible way to evaluate PN pathologies. [43][44][45][46][47]…”

Section: T2 Mappingmentioning

confidence: 99%

Technical Update on MR Neurography

Martín-Noguerol

Montesinos

Hassankhani

et al. 2022

Semin Musculoskelet Radiol

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Imaging evaluation of peripheral nerves (PNs) is challenging. Magnetic resonance imaging (MRI) and ultrasonography are the modalities of choice in the imaging assessment of PNs. Both conventional MRI pulse sequences and advanced techniques have important roles. Routine MR sequences are the workhorse, with the main goal to provide superb anatomical definition and identify focal or diffuse nerve T2 signal abnormalities. Selective techniques, such as three-dimensional (3D) cranial nerve imaging (CRANI) or 3D NerveVIEW, allow for a more detailed evaluation of normal and pathologic states. These conventional pulse sequences have a limited role in the comprehensive assessment of pathophysiologic and ultrastructural abnormalities of PNs. Advanced functional MR neurography sequences, such as diffusion tensor imaging tractography or T2 mapping, provide useful and robust quantitative parameters that can be useful in the assessment of PNs on a microscopic level. This article offers an overview of various technical parameters, pulse sequences, and protocols available in the imaging of PNs and provides tips on avoiding potential pitfalls.

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“…Regarding the nerve in total, T2 values typically reported in the literature range from 45 to 70 ms at 3T. However, multiple water components with different relaxation times are present, most studies reporting three or more components ranging from 20 to 200 ms [ 18 ]. T2 is the transverse or spin–spin relaxation.…”

Section: Introductionmentioning

confidence: 99%

Variable echo time imaging for detecting the short T2* components of the sciatic nerve: a validation study

Felisaz¹,

Belatti²,

Deligianni

et al. 2020

Magn Reson Mater Phy

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Objective The aim of this study was to develop and validate an MRI protocol based on a variable echo time (vTE) sensitive to the short T2* components of the sciatic nerve. Materials and methods 15 healthy subjects (M/F: 9/6; age: 21–62) were scanned at 3T targeting the sciatic nerve at the thigh bilaterally, using a dual echo variable echo time (vTE) sequence (based on a spoiled gradient echo acquisition) with echo times of 0.98/5.37 ms. Apparent T2* (aT2*) values of the sciatic nerves were calculated with a mono-exponential fit and used for data comparison. Results There were no significant differences in aT2* related to side, sex, age, and BMI, even though small differences for side were reported. Good-to-excellent repeatability and reproducibility were found for geometry of ROIs (Dice indices: intra-rater 0.68–0.7; inter-rater 0.70–0.72) and the related aT2* measures (intra-inter reader ICC 0.95–0.97; 0.66–0.85) from two different operators. Side-related signal-to-noise-ratio non-significant differences were reported, while contrast-to-noise-ratio measures were excellent both for side and echo. Discussion Our study introduces a novel MR sequence sensitive to the short T2* components of the sciatic nerve and may be used for the study of peripheral nerve disorders.

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T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression

Cited by 12 publications

References 47 publications

Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry

Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry

Technical Update on MR Neurography

Variable echo time imaging for detecting the short T2* components of the sciatic nerve: a validation study

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