T2 Mapping with and without Fat-Suppression to Predict Treatment Response to Intravenous Glucocorticoid Therapy for Thyroid-Associated Ophthalmopathy

Zhai, Linhan; Wang, Qiuxia; Liu, Ping; Luo, Ban; Yuan, Gang; Zhang, Jing

doi:10.3348/kjr.2021.0627

Cited by 5 publications

(13 citation statements)

References 32 publications

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“…Four major MRI sequences were utilized across all included studies: T2-weighted imaging in 21 studies (87.5%), 8,14,23,28–31,37,38,40,43–53 T1-weighted imaging was used in 13 of the included studies (54.2%), 23,24,29,38,40,44,46–50,52,53 diffusion-weighted/diffusion-tensor imaging (DWI/DTI) in 5 studies (20.8%), 38,41,46,47,49 and STIR in 4 studies (16.7%). 12,14,28,48 The most common parameters quantified were signal intensity ratio (SIR) in 10 studies (41.7%), 8,12,14,23,24,28,29,37,40,53 T2RT in 8 studies (33.3%), 8,28,30,31,43,45,50,51 and apparent diffusion coefficient (ADC) in 5 studies (20.8%). 38,40,46,47,49 The following imaging findings were reported to correlate with TED activity across multiple studies: longer T2RT and higher SIR.…”

Section: Resultsmentioning

confidence: 99%

“…28,30,31,50,51 Four of these 5 studies concluded that T2RT may predict response to glucocorticoids. 30,31,50,51 DTI parameters were found to distinguish TED patients with DON from those without DON in 2 studies, 38,41 while extraocular muscle (EOM) volume was found to be associated with DON in 1 study. 52 Two studies concluded that MRI could not predict response to orbital radiotherapy.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four articles 8,12,14,23,24,[28][29][30][31]37,38,40,41,[43][44][45][46][47][48][49][50][51][52][53] were identified as meeting the inclusion criteria, and their full text was subsequently reviewed. The extracted information and outcomes are displayed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Four included studies implemented T2-relaxation mapping to examine EOMs in TED, finding that it had the potential to stage disease and even detect EOM dysfunction before frank changes on MRI. 8,28,50,51 Overall, T2-mapping represents a growing area of research that allows for a more comprehensive assessment of orbital MRI sequences. Its counterpart on T1-weighted imaging demonstrates similar promise.…”

Section: Discussionmentioning

confidence: 99%

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Magnetic Resonance Imaging in the Management of Thyroid Eye Disease: A Systematic Review

Vaishnav,

Mawn

2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: MRI may potentially detect active thyroid eye disease prior to elevation of clinical activity score. We aimed to systematically review the existing literature pertaining to MRI thyroid eye disease and to assess the role of MRI in the diagnosis of thyroid eye disease. Methods: A Population, Intervention, Comparison, Outcome/Preferred Reporting Items for Systematic Reviews and Meta-Analyses selection criteria was applied to identify studies for inclusion published between the years 2000 and 2023. Results: Twenty-four articles were identified for inclusion in the systematic review. All included studies utilized MRI as the imaging modality. MRI sequences used included T2-weighted imaging in 87.5%, T1-weighted imaging in 54.2%, diffusion-weighted imaging in 20.8%, and short tau inversion recovery in 16.7%. The most common parameters quantified were signal intensity ratio in 10 studies (41.7%) and T2-relaxation time in 8 studies (33.3%). Signal intensity ratio and T2-relaxation time were shown to correlate with clinical activity score and identify the phase of the disease. Conclusions: MRI has untapped potential for further elucidating the highly complex biological processes in thyroid eye disease. As we move away from clinical activity score as a predictor of response to biologic therapy, MRI may prove more important than ever in the risk-benefit analysis around the use of immunomodulators.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Magnetic Resonance Imaging in the Management of Thyroid Eye Disease: A Systematic Review

Vaishnav,

Mawn

2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

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“…Future studies should focus on developing new sequences to improve temporal resolution, such as T1 rho, a relatively new sequence that has better characterization in injury than T1 ( 130 ). The improvement of image analysis methods for imaging, including histogram analysis, also provides more accurate ways for GO evaluation ( 131 , 132 ). Furthermore, radiomics and deep learning have been widely used in image segmentation, ROI extraction, and automatic analysis to assist in diagnosis.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Current insights of applying MRI in Graves’ ophthalmopathy

Song

Luo

et al. 2022

Front. Endocrinol.

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Graves’ ophthalmopathy (GO) is an autoimmune disease related to Grave’s disease (GD). The therapeutic strategies for GO patients are based on precise assessment of the activity and severity of the disease. However, the current assessment systems require development to accommodate updates in treatment protocols. As an important adjunct examination, magnetic resonance imaging (MRI) can help physicians evaluate GO more accurately. With the continuous updating of MRI technology and the deepening understanding of GO, the assessment of this disease by MRI has gone through a stage from qualitative to precise quantification, making it possible for clinicians to monitor the microstructural changes behind the eyeball and better integrate clinical manifestations with pathology. In this review, we use orbital structures as a classification to combine pathological changes with MRI features. We also review some MRI techniques applied to GO clinical practice, such as disease classification and regions of interest selection.

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Application of Quantitative MRI in Thyroid Eye Disease: Imaging Techniques and Clinical Practices

Zhang,

Lu,

Liu

et al. 2023

Magnetic Resonance Imaging

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Thyroid eye disease (TED) is a complex autoimmune disorder that impairs various orbital structures, leading to cosmetic damage and vision loss. Magnetic resonance imaging (MRI) is a fundamental diagnostic tool utilized in clinical settings of TED, for its accurate demonstration of orbital lesions and indication of disease conditions. The application of quantitative MRI has brought a new prospect to the management and research of TED, offering more detailed information on morphological and functional changes in the orbit. Therefore, many researchers concentrated on the implementation of different quantitative MRI techniques on TED for the exploration of clinical practices. Despite the abundance of studies utilizing quantitative MRI in TED, there remain considerable barriers and disputes on the best exploitation of this tool. This could possibly be attributed to the complexity of TED and the fast development of MRI techniques. It is necessary that clinical and radiological aspects of quantitative MRI in TED be better integrated into comprehensive insights. Hence, this review traces back 30 years of publications regarding quantitative MRI utilized in TED and elucidates this promising application in the facets of imaging techniques and clinical practices. We believe that a deeper understanding of the application of quantitative MRI in TED will enhance the efficacy of the multidisciplinary management of TED.Level of Evidence2Technical EfficacyStage 3

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T2 Mapping with and without Fat-Suppression to Predict Treatment Response to Intravenous Glucocorticoid Therapy for Thyroid-Associated Ophthalmopathy

Cited by 5 publications

References 32 publications

Magnetic Resonance Imaging in the Management of Thyroid Eye Disease: A Systematic Review

Magnetic Resonance Imaging in the Management of Thyroid Eye Disease: A Systematic Review

Current insights of applying MRI in Graves’ ophthalmopathy

Application of Quantitative MRI in Thyroid Eye Disease: Imaging Techniques and Clinical Practices

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