T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology After Acute Kidney Injury in Mice

Hueper, Katja; Rong, Song; Gutberlet, Marcel; Hartung, Dagmar; Mengel, Michael; Xia, Lu; Haller, Hermann; Wacker, Frank; Meier, Martin; Gueler, Faikah

doi:10.1097/rli.0b013e31829d0414

Cited by 103 publications

(133 citation statements)

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“…AKI was induced by transient unilateral clamping of the right renal pedicle for either 35 min (35 min IRI, moderate AKI, n=26) or 45 min (45 min IRI, severe AKI, n= 23), as described previously [25][26][27]. In brief, mice were anaesthetised with isoflurane.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…For cardiac imaging T1-and T2-mapping techniques have already been established for clinical use and seem promising to quantify diffuse and focal myocardial edema and fibrosis in patients with myocardial infarction and cardiomyopathy [21][22][23][24]. We recently showed that T2-values are increased in the acute phase after AKI depending on its severity and are unchanged in the chronic phase [25]. The ability of T1-mapping to determine the severity of renal damage after AKI and to differentiate acute and chronic renal changes has not been investigated so far.…”

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confidence: 97%

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T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

et al. 2014

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Section: Experimental Animalsmentioning

confidence: 99%

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T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

et al. 2014

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“…Notwithstanding this success, our findings generated novel questions about the renal These efforts should make use of the advanced capabilities of MR-PHYSIOL by including parallel imaging techniques to improve the temporal resolution [59][60][61][62], by investing into dual contrast techniques for simultaneous T 2 */T 2 weighted MRI [63], by driving T 2 * mapping techniques free of image distortion [64] but also MR based assessment of renal blood volume [65] and by probing tubular volume fraction using diffusion weighted or intra-voxel incoherent motion techniques [43,[66][67][68][69], while blood sampling may be employed to examine the role of shifts in the oxyHb dissociation curve. These explorations are essential before the quantitative capabilities of parametric MRI can be translated from experimental research to improved clinical understanding of hemodynamics/oxygenation in kidney disorders.…”

Section: Correlations Of Physiological and Mr Parametersmentioning

confidence: 99%

Detailing the Relation Between Renal T2* and Renal Tissue pO2 Using an Integrated Approach of Parametric Magnetic Resonance Imaging and Invasive Physiological Measurements

Pohlmann¹,

Arakelyan²,

Hentschel³

et al. 2014

Investigative Radiology

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Objectives: This study is designed to detail the relation between renal T 2 * and renal tissue pO 2 using an integrated approach that combines parametric MRI and quantitative physiological measurements (MR-PHYSIOL). correlations for the outer medulla and showed that extrapolation of results obtained for one renal layer to other renal layers must be made with due caution. For T 2 * to RBF relation significant Spearman correlations were deduced for all renal layers and for all interventions. Materials and Methods

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“…2A). Relaxation time (T1 and T2) is a highly reliable surrogate for water distribution/state in both plant (Van As and van Duynhoven, 2013) and animal (Hueper et al, 2013;Wu et al, 2014) tissue. In living plant tissue containing vacuolated cells, the majority of the water present is contained in the vacuoles, and as a result, T2 images are dominated by vacuolar water (Van As et al, 2009).…”

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Metabolic architecture of the cereal grain and its relevance to maximize carbon use efficiency

et al. 2015

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Here, we have characterized the spatial heterogeneity of the cereal grain's metabolism and demonstrated how, by integrating a distinct set of metabolic strategies, the grain has evolved to become an almost perfect entity for carbon storage. In vivo imaging revealed light-induced cycles in assimilate supply toward the ear/grain of barley (Hordeum vulgare) and wheat (Triticum aestivum). In silico modeling predicted that, in the two grain storage organs (the endosperm and embryo), the light-induced shift in solute influx does cause adjustment in metabolic flux without changes in pathway utilization patterns. The enveloping, leaf-like pericarp, in contrast, shows major shifts in flux distribution (starch metabolism, photosynthesis, remobilization, and tricarboxylic acid cycle activity) allow to refix 79% of the CO 2 released by the endosperm and embryo, allowing the grain to achieve an extraordinary high carbon conversion efficiency of 95%. Shading experiments demonstrated that ears are autonomously able to raise the influx of solutes in response to light, but with little effect on the steady-state levels of metabolites or transcripts or on the pattern of sugar distribution within the grain. The finding suggests the presence of a mechanism(s) able to ensure metabolic homeostasis in the face of short-term environmental fluctuation. The proposed multicomponent modeling approach is informative for predicting the metabolic effects of either an altered level of incident light or a momentary change in the supply of sucrose. It is therefore of potential value for assessing the impact of either breeding and/or biotechnological interventions aimed at increasing grain yield.Raising the productivity of a given crop genotype requires an increase in the plant's ability to efficiently respond to a changeable environment. At the physiological level, this involves adjustments to the photosynthetic activity of its leaves, to the control of assimilate movement from source to sink, and to the efficiency of assimilate storage. The manipulation of the plant's efficiency to fix carbon, to use energy and nutrients, and to utilize water has been suggested as a route for improving crop productivity (Amthor 2010;De Block and Van Lijsebettens, 2011). Particular attention has been devoted to the cereals, given their central role in the human diet. While the necessary integration of physiological and developmental processes in all plants relies on the transmission of hormonal, metabolic, and other signals through the vascular system (van Bel et al., 2013), this is not the case in the cereal grain, because this network does not extend beyond the pericarp, a maternal structure that encloses the filial storage organs (embryo and endosperm; Radchuk and Borisjuk, 2014). The isolation of the filial from the maternal tissues in the cereal grain creates a complex metabolic system, involving, at the least, a tripartite interaction between the pericarp, endosperm, and embryo. These three grain components in effect form an interactive system of autonomous...

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T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology After Acute Kidney Injury in Mice

Cited by 103 publications

References 40 publications

T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

Detailing the Relation Between Renal T2* and Renal Tissue pO2 Using an Integrated Approach of Parametric Magnetic Resonance Imaging and Invasive Physiological Measurements

Metabolic architecture of the cereal grain and its relevance to maximize carbon use efficiency

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