T2 Relaxometry MRI Predicts Cerebral Palsy in Preterm Infants

Chen, L.-W.; Wang, S.-T.; Huang, Chunmao; Tu, Yi Fang; Tsai, Yuh Shyan

doi:10.3174/ajnr.a5501

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…Our data show that, in mildly affected CMV‐infected fetuses, the upper SFA was significantly larger compared with controls, probably suggesting delayed cortical maturation of the superior operculization process of the SF 41,42 . Our findings agree with those of Pooh et al 43 ,.…”

Section: Discussionsupporting

confidence: 92%

Brain cortical maturation assessed by magnetic resonance imaging in unaffected or mildly affected fetuses with cytomegalovirus infection

Hawkins-Villarreal

Moreno-Espinosa

Castillo

et al. 2023

Ultrasound in Obstet & Gyne

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What are the novel findings of this work?This is the first study demonstrating delayed cortical maturation on prenatal magnetic resonance imaging (MRI) in unaffected or mildly affected fetuses with congenital cytomegalovirus (CMV) infection. CMV-infected fetuses had significantly reduced calcarine and parieto-occipital sulci depth and larger Sylvian fissure angles compared with healthy controls. Mildly affected CMV-infected fetuses also demonstrated lower cortical development grading in the parietal and temporal areas compared with controls. What are the clinical implications of this work?Fetal CMV infection, even if it is considered of good prognosis, seems to be associated with an altered pattern of fetal brain cortical maturation compared with healthy non-infected fetuses. Our results reinforce the use of MRI as a complementary tool for assessing brain structure at 32 weeks' gestation in CMV-infected fetuses even if they do not exhibit ultrasound abnormalities.

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Section: Discussionsupporting

confidence: 92%

Brain cortical maturation assessed by magnetic resonance imaging in unaffected or mildly affected fetuses with cytomegalovirus infection

Hawkins-Villarreal

Moreno-Espinosa

Castillo

et al. 2023

Ultrasound in Obstet & Gyne

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“…Our analysis also highlighted the insula network as significantly different for fetuses with ToF or TGA compared to controls, in accordance with previous work noting delayed opercular development in term infants with complex CHD (Glauser et al, 1990, Masoller et al, 2016, Ortinau et al, 2019, Peng et al, 2016). Operculation of the insula is usually complete at term (Goldstein et al, 2017), however an open operculum and exposed insular cortex have been associated with neurodevelopmental delays in CHD and more broadly in other patient populations (Mahle et al, 2000, Licht et al, 2009, Tatum et al, 1989, Chen et al, 1996). Interestingly, TGA was not significantly different from controls for any of the networks except the insula.…”

Section: Discussionmentioning

confidence: 99%

Structural covariance networks in the fetal brain reveal altered neurodevelopment for specific subtypes of congenital heart disease

Wilson,

Cromb,

Bonthrone

et al. 2024

Preprint

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BackgroundAltered structural brain development has been identified in fetuses with Congenital Heart Disease (CHD), suggesting that the neurodevelopmental impairment observed later in life might originate in utero. There are many interacting factors that may perturb neurodevelopment during the fetal period and manifest as structural brain alterations, such as altered cerebral substrate delivery and aberrant fetal hemodynamics.MethodsWe extracted structural covariance networks (SCNs) from the log Jacobian determinants of 429 in utero T2w MRI scans, (n = 67 controls, 362 CHD) acquired during the third trimester. We fit general linear models to test whether age, sex, expected cerebral substrate delivery and CHD diagnosis were significant predictors of structural covariance.ResultsWe identified significant effects of age, sex, cerebral substrate delivery, and specific CHD diagnosis across a variety of SCNs, including primary motor and sensory cortices, cerebellar regions, frontal cortex, extra-axial CSF, thalamus, brainstem, and insula, consistent with widespread coordinated aberrant maturation of specific brain regions over the third trimester.ConclusionsSCNs offer a sensitive, data-driven approach to explore whole-brain structural changes without anatomical priors. We used them to stratify a heterogenous CHD patient cohort, highlighting similarities and differences between diagnoses during fetal neurodevelopment. Although there was a clear effect of abnormal fetal hemodynamics on structural brain maturation, our results suggest that this alone does not explain all the variation in brain development between individuals with CHD.

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“…Relaxometry is sensitive to the brain's composition and microstructure by reflecting the magnetization relaxation characteristics of brain tissue (10). Therefore, relaxometry characteristics have been investigated in several brain imaging studies (11)(12)(13)(14). Relaxometry studies have also been conducted on other organs, such as the cartilage (15), kidney (16), etc.…”

Section: Introductionmentioning

confidence: 99%

Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty

Li¹,

Chen²,

Wu³

et al. 2021

Quant Imaging Med Surg

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Background: Frailty is a geriatric condition characterized by a decreased reserve. The Edmonton frailty scale (EFS) has been widely used as an assessment tool in clinical practice. However, the brain's underlying pathophysiological changes in frailty and their associations with the EFS remain unclear. This study aimed to explore the associations between brain volumetry and relaxometry signatures and the EFS (and each domain score of the EFS) in frailty.Methods: A total of 40 non-demented subjects were enrolled in this prospective study. Frailty assessment was performed for each subject according to the EFS. All subjects underwent synthetic magnetic resonance imaging (MRI) (MAGnetic resonance image Compilation, MAGiC) and three-dimensional fast spoiled gradient-recalled echo (3D-FSPGR) T1-weighted structural image acquisitions on a 3.0 T MR scanner.Brain segmentation was performed based on quantitative values obtained from the MAGiC and 3D-FSPGR images. Volumetry and relaxometry of the global brain and regional gray matter (GM) were also obtained.The associations between the total EFS score (and the score of each domain) and the brain's volumetry and relaxometry were investigated by partial correlation while eliminating the effects of age. Multiple comparisons of regional GM volumetry and relaxometry analyses were controlled by false discovery rate (FDR) correction. All data were analyzed using the SPSS 13.0 statistical package (IBM, Armonk, NY, USA) and MATLAB (MathWorks, Natick, MA, USA).Results: For global volumetry, significant correlations were found between multiple global volumetry parameters and the EFS, as well as the cognition score, functional independence score, nutrition score, and functional performance score (P<0.05). For global relaxometry, notable positive correlations were found between the T2 values of gray and white matter (WM) and the EFS (r=0.357, P=0.026; r=0.357, P=0.026, respectively). Significant correlations were also identified between the T2 value of GM, the T1, T2, and

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T2 Relaxometry MRI Predicts Cerebral Palsy in Preterm Infants

Cited by 13 publications

References 24 publications

Brain cortical maturation assessed by magnetic resonance imaging in unaffected or mildly affected fetuses with cytomegalovirus infection

Brain cortical maturation assessed by magnetic resonance imaging in unaffected or mildly affected fetuses with cytomegalovirus infection

Structural covariance networks in the fetal brain reveal altered neurodevelopment for specific subtypes of congenital heart disease

Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty

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