T2 signal intensity as an imaging biomarker for patients with superficial Fibromatoses of the hands (Dupuytren’s disease) and feet (Ledderhose disease) undergoing definitive electron beam irradiation

Banks, James; Wolfson, Aaron H.; Subhawong, Ty K.

doi:10.1007/s00256-017-2792-5

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…Five studies reported the use of US or MRI to evaluate different operative and non-operative treatment modalities (Table 7). Three studies used US or MRI to follow-up non-invasive treatment [36–38]. In the first study, US was used to follow-up cross-frictional treatment of a patient with early stage DD, which is a therapy that aims to reduce contracture by stretching the Dupuytren tissue [36].…”

Section: Resultsmentioning

confidence: 99%

“…A significant decrease in size was detected from pre-injection to 6 months follow-up and to the final follow-up. In the third study, MRI was used to follow-up size and signal intensity of superficial fibromatoses of the hands and feet in patients undergoing electron beam therapy (EBT) [38]. Intensity decreased significantly, which was attributed to progression from the proliferative to the residual stage.…”

Section: Resultsmentioning

confidence: 99%

“…As these patients do not have contractures yet, there is need for an alternative reliable outcome parameter. This is why several studies report the use of imaging to follow-up treatment outcome of non-surgical procedures for patients with early DD [36–38]. In our opinion, the use of US and MRI to follow-up size and signal of early DD nodules is most relevant as, currently, the only other reliable measurement instruments for patients without contractures is physical examination, which only measures area of disease in one plane and measures the projection of DD on the overlying skin [10].…”

Section: Discussionmentioning

confidence: 99%

“…Ten studies were case-reports, including only 1 patient [18–23, 25, 27, 32, 36]. In three other studies, less than 10 DD patients were included [24, 38, 40] and in one study the number of observed patients was not described [29]. Of the 9 other studies that did describe a larger cohort of DD patients [26, 28, 31, 35, 37, 39], two studies were conference proceedings [33, 34] and only 1 study included a control group with healthy volunteers for a part of the study [30].…”

Section: Discussionmentioning

confidence: 99%

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Imaging for Dupuytren disease: a systematic review of the literature

Molenkamp

Straalen

Werker

et al. 2019

BMC Musculoskelet Disord

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Background As treatment of Dupuytren disease (DD) is expected to shift towards prevention of progression, the use of imaging in patients with DD becomes more important. In this systematic review an overview is given of the different methods for and applications of imaging for DD that have been described. Methods The MEDLINE and EMBASE databases were searched for articles reporting the use of imaging in patients with DD, published before May 17, 2018. Studies were systematically examined in two rounds by two observers according to the PRISMA systematic. All studies containing original data on imaging for DD were considered for inclusion. Results Three hundred and seven unique studies were identified, of which 23 were included in the study. Only studies on the use of ultrasound (US) and magnetic resonance imaging (MRI) were identified. Broadly, articles could be divided into 5 categories. Seven studies were found on diagnosis, two on measurement of disease extent, four on measurement of disease activity, seven on guidance of minimally invasive procedures and five studies on evaluation of treatment. According to the Oxford CEBM, the levels of evidence were low, ranging from level 3 to 5. Conclusions A variety of applications for US and MRI for patients with DD has been described. Based on the results of this review, the largest value for imaging lies in the measurement of disease activity and the follow-up of treatment of patients with early stage disease. Unfortunately, the overall level of evidence of the available literature was low. Future research is necessary to define the exact value of US and MRI in the management of patients with DD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Imaging for Dupuytren disease: a systematic review of the literature

Molenkamp

Straalen

Werker

et al. 2019

BMC Musculoskelet Disord

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“…On MRI, plantar fibromas are seen as small to medium-sized fusiform-shaped nodule or clustered nodules attached to and extending along the plantar aponeurosis ('fascial tail sign'), usually the medial cord. T2 hyperintense (relative to muscle) lesions with avid contrast enhancement tend to be actively growing lesions, containing proliferative fibroblastic tissue, that are more responsive to electron beam irradiation therapy, while T2 isointense or hypointense lesions with poor enhancement tend to be quiescent lesions, containing mature collagenous tissue (27) .…”

Section: Plantar Fibromatosis (Ledderhose Disease)mentioning

confidence: 99%

High-resolution ultrasound and MRI in the evaluation of the forefoot and midfoot

Reijnierse,

Griffith

2023

J Ultrason

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Radiography is the appropriate initial imaging modality to assess for midfoot and forefoot pathology before turning to advanced imaging techniques. While most lesions of the mid- and forefoot can be diagnosed clinically, the exact nature and severity of the pathology is often unclear. This review addresses the use of the ultrasound, as well as the added value of magnetic resonance imaging, in diagnosing conditions of the mid- foot and forefoot. Ultrasound allows a dynamic assessment as well as enabling imaging-guided interven- tions for diagnostic and therapeutic purposes. Practical tips for optimal examination of this area with ultra- sound and magnetic resonance imaging are provided. Metatarsal stress fracture, Chopart’s injury, Lisfranc injury, as well as the 1st metatarsophalangeal joint injury and lesser metatarsophalangeal plantar plate injury are injuries unique to the mid- and forefoot. The imaging anatomy of the 1st and lesser metatarsophalan- geal joints is reviewed, as such knowledge is key to correctly assessing injury of these joints. Characteristic imaging features of masses commonly encountered in the mid- and forefoot, such as ganglion cyst, Morton neuroma, gouty tophus, plantar fibroma, foreign body granuloma, and leiomyoma are reviewed. The use of ultrasound and magnetic resonance imaging in assessing degenerative and inflammatory joint disorders, and in particular rheumatoid arthritis, of the mid- and forefoot region is also reviewed. In summary, when necessary, most lesions of the mid-and forefoot can be adequately assessed with ultrasound, supplemented on occasion with radiographs, computed tomography, or magnetic resonance imaging.

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