T2 tumors larger than five centimeters in diameter can be upgraded to T3 in non–small cell lung cancer

Carbone, Emanuela; Asamura, Hisao; Takei, Hidefumi; Kondo, Haruhiko; Suzuki, Kenji; Miyaoka, Etsuo; Tsuchiya, Ryosuke; Motta, G

doi:10.1067/mtc.2001.116949

Cited by 51 publications

(46 citation statements)

References 17 publications

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“…consistent with previous findings reported by Carbone and colleagues [2]. The appropriateness of initial operation in patients with pleural invasion must be determined carefully in patients with the disease.…”

supporting

confidence: 78%

“…However, earlier studies indicated that the surgical outcome of NSCLC with large tumors more than 5 cm in diameter is poor. Carbone and associates [2] reported that 5-year survival rate of 111 NSCLC patients with T2 tumors more than 5 cm in diameter was 35.1%. In their series, the 9 significant survival difference based on this threshold remained in N0 and N2-3 status.…”

Section: Commentsmentioning

confidence: 99%

“…As tumor size is crucial for the oncological outcome in NSCLC patients, the effects of surgical treatment are still uncertain in patients with large tumors. Although lung cancer is considered a surgically treatable disease in the relatively early stages, recent retrospective clinical assessment showed that a diameter of more than 5 cm is the threshold predicting poor prognosis in lung carcinoma, suggesting that the current staging system should be revised [1][2][3][4]. On the other hand, some investigators suggested that localized large tumors also include those with less metastatic potential [5].…”

Section: Introductionmentioning

confidence: 99%

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Surgical Results in T2N0M0 Nonsmall Cell Lung Cancer Patients With Large Tumors 5 cm or Greater in Diameter: What Regulates Outcome?

Ohta

Waseda

Minato

et al. 2006

The Annals of Thoracic Surgery

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Background:We assessed the surgical results along with the clinical and biological features of non-small cell lung cancer (NSCLC) patients with localized large tumors. Methods:The study population consisted of 86 NSCLC patients who underwent complete resection of tumors 5 cm or larger in diameter in stage IB (T2N0M0). We immunohistochemically assessed the expression of angiostatin and endostatin. Results:The median tumor size was 6.0 cm (range, 5-14 cm). The operative procedures used were lobectomy in 71 cases, bilobectomy in 8 cases, and pneumonectomy in 11 cases. Fifty patients (58.1%) relapsed during the mean follow-up period of 33.6 ± 4.5 months. The median disease-free interval (DFI) was 9 months. Of 44 recurrent patients whose DFI could be identified, 25 patients (56.8%) relapsed within 12 months after the operation. The overall 5-and 10-year survival rates were 42.0% and 24.2%, respectively.Multivariate analysis showed that the degree of pleural involvement and angiostatin expression within the tumor were independent prognostic indicators. The endostatin expression within tumors also had a weaker relationship with outcome.Conclusions: Long-term surgical results were poor and early relapse was common in this cohort. In addition to pleural involvement, the tumor-induced expression of angiostatin and endostatin merit further investigation to gain possible insights into selection of patients who will benefit from surgery as the first line treatment.2

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confidence: 78%

Section: Commentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical Results in T2N0M0 Nonsmall Cell Lung Cancer Patients With Large Tumors 5 cm or Greater in Diameter: What Regulates Outcome?

Ohta

Waseda

Minato

et al. 2006

The Annals of Thoracic Surgery

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“…A great number of studies have demonstrated that the survival of patients with SCCs is better than those with adenocarcinomas. Similarly, Carbone et al [16] detected that five-year survival probability in SCCs was better than adenocarcinomas (48.8% and 40.9%, respectively). Also, in another study, five-year survival in SCC was better than adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…In peripheral tumors, adenocarcinoma incidence was 37.4% and SCC incidence was 45%, and although not statistically significant, there was a dominance of SCC. [16] According to the literature, adenocarcinoma incidence is higher in females. [17] We detected that the incidence of EBL was significantly lower in females.…”

Section: Discussionmentioning

confidence: 99%

Does endobronchial lesion affect the lymph node status in non-small cell lung cancer?

Akçay¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada küçük hücreli dışı akciğer kanserinde endobronşiyal lezyon ile hiler veya mediastinal lenf nodu metastazı arasında ilişki olup olmadığı değerlendirildi. Bul gu lar: Endobronşiyal lezyonu olan (n=174) ve olmayan hasta gruplarında (n=513) ki-kare analizi ile yapılan değerlendirmede endobronşiyal lezyon varlığı ve hiler lenf nodu metastazı durumu arasında anlamlı bir ilişki saptanır iken (p= 0.014) endobronşiyal lezyon varlığı ve aynı taraf mediastinal lenf nodu metastazı durumu arasında anlamlı bir ilişki saptanmadı (p= 0.383). Endobronşiyal lezyonu olan ve olmayan hastalarda beş yıllık sağkalım sırası ile %58.6 ve %40.2 olup aralarında istatistiksel olarak anlamlı farklılık vardı (p<0.001).So nuç: Endobronşiyal lezyonu olan küçük hücreli dışı akciğer kanseri olgularında hiler lenf nodu metastazı anlamlı olarak daha sık görülmektedir. Bu durum peribronşiyal lenfatikler aracılığı ile metastaz gelişebileceği yönünde şüphe uyandırmaktadır.Anah tar söz cük ler: Endobronşiyal lezyon; akciğer kanseri; lenf nodu metastazı. ABSTRACTBackground: This study aims to evaluate whether or not there is a relationship between endobronchial lesion and hilar and/or mediastinal lymph node metastasis in non-small cell lung cancer.

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Staging Principles in Lung Cancer

Gangadharan

2009

Endobronchial Ultrasound

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T2 tumors larger than five centimeters in diameter can be upgraded to T3 in non–small cell lung cancer

Cited by 51 publications

References 17 publications

Surgical Results in T2N0M0 Nonsmall Cell Lung Cancer Patients With Large Tumors 5 cm or Greater in Diameter: What Regulates Outcome?

Surgical Results in T2N0M0 Nonsmall Cell Lung Cancer Patients With Large Tumors 5 cm or Greater in Diameter: What Regulates Outcome?

Does endobronchial lesion affect the lymph node status in non-small cell lung cancer?

Staging Principles in Lung Cancer

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