2024
DOI: 10.1101/2024.04.04.588121
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T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome ofEscherichia coliduring infection through a phage-encoded decapping enzyme

Maik Wolfram-Schauerte,
Anastassiya Moskalchuk,
Nadiia Pozhydaieva
et al.

Abstract: Nicotinamide adenine dinucleotide (NAD) serves as a cap-like structure on cellular RNAs (NAD-RNAs) in all domains of life including the bacterium Escherichia coli. NAD also acts as a key molecule in phage-host interactions, where bacterial immune systems deplete NAD to abort phage infection. Nevertheless, NAD-RNAs have not yet been identified during phage infections of bacteria and the mechanisms of their synthesis and degradation are unknown in this context. The T4 phage that specifically infects E. coli pres… Show more

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