T4-Rektumkarzinom Operative und multimodale Therapie

Abstract

Our data on preoperative combined treatment in locally advanced T4 rectal cancer revealed encouraging downstaging, local control, and survival rates.

Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer

“…Treatment consisted of hypofractionated radiotherapy with concomitant capecitabine and oxaliplatin, rectal metronidazole and capacitative hyperthermia with a target temperature of 41-45 C. The authors report a complete resection rate of 92% and a local failure rate of 13.6% after a median follow-up of 24.9 months [19]. These numbers are superior to data reported before for this population with a very high risk for local failure [20]. Unfortunately the concomitant use of several potential radiosensitisers with an experimental hypofractionation scheme does not allow the impact of hyperthermia to be determined in that trial.…”

Incidence of Metachronous Distant Metastasis and ypN Classification Influence Patient Survival in Endosonographically Confirmed uT3 Rectal Cancer after Neoadjuvant Therapy and R0 Resection: A Historical Cohort Analysis

“…It is difficult to compare the response rates of neoadjuvant pretreated rectal cancer patients with our results due to many studies using heterogeneous cohorts consisting of T3 and T4Nx tumors [21,22,23,24,25,26]. Some authors employed the UICC system for the calculation of the response rate [14].…”

Treatment of advanced rectal cancer in a patient after combined pancreas?kidney transplantation

“…The radiation field included the pelvis with the rectum and the mesorectum. Pre-operative radio-chemotherapy was scheduled according to the protocol of Schlag et al [15]. Radiotherapy was planned three-dimensionally with a three-field technique (one postero-anterior and two lateral fields).…”