T5. Brain Before Behavior: Temporal Dynamics in the Treatment of Social Anxiety - Neural Changes Occur Early and Precede Clinical Improvement

Månsson, Kristoffer; Wager, Tor D.; Isacsson, Nils Hentati; Kolbeinsson, Örn; Andersson, Gerhard; Fischer, Håkan; Furmark, Tomas

doi:10.1016/j.biopsych.2018.02.341

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“…In total, 265 patients [117 men, 148 women; mean age (SD): 33.5 (10.3) years] diagnosed with DSM-IV SAD [45] and 164 healthy controls [82 men, 82 women; mean age: 30.9 (9.9) years], answered paper-and-pen version of the personality scales NEO-PI-R and KSP. All participants were volunteers in neuroimaging treatment trials, data being collected from 1998 to 2018, as described elsewhere [46][47][48][49][50][51][52][53][54]. NEO-PI-R data were collected from trials conducted from 2003 and onwards.…”

Section: Participants Characteristics and General Study Set-upmentioning

confidence: 99%

“…Exclusion criteria were: previous or current neurological and somatic illnesses, current predominant axis I mental disorder other than SAD (e.g. bipolar or severe major depressive disorder, psychosis), pregnancy, menopause, psychological or psychotropic treatment that was ongoing or had ended within the previous three months, alcohol and narcotics addiction or abuse, age outside the range of 18-65, or other characteristics that could be expected to interfere with the original neuroimaging study such as claustrophobia or metal implants [46][47][48][49][50][51][52][53][54].…”

Section: Participants Characteristics and General Study Set-upmentioning

confidence: 99%

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Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder

et al. 2020

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Social anxiety disorder (SAD) can come in different forms, presenting problems for diagnostic classification. Here, we examined personality traits in a large sample of patients (N = 265) diagnosed with SAD in comparison to healthy controls (N = 164) by use of the Revised NEO Personality Inventory (NEO-PI-R) and Karolinska Scales of Personality (KSP). In addition, we identified subtypes of SAD based on cluster analysis of the NEO-PI-R Big Five personality dimensions. Significant group differences in personality traits between patients and controls were noted on all Big Five dimensions except agreeableness. Group differences were further noted on most lower-order facets of NEO-PI-R, and nearly all KSP variables. A logistic regression analysis showed, however, that only neuroticism and extraversion remained significant independent predictors of patient/control group when controlling for the effects of the other Big Five dimensions. Also, only neuroticism and extraversion yielded large effect sizes when SAD patients were compared to Swedish normative data for the NEO-PI-R. A two-step cluster analysis resulted in three separate clusters labelled Prototypical (33%), Introvert-Conscientious (29%), and Instable-Open (38%) SAD. Individuals in the Prototypical cluster deviated most on the Big Five dimensions and they were at the most severe end in profile analyses of social anxiety, self-rated fear during public speaking, trait anxiety, and anxiety-related KSP variables.

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