T606 Comparison of Local Anesthetic Effects of Tramadol and Lidocaine Used Subcutaneously in Minor Surgeries With Local Anesthesia

Vahabi, Sepideh; Akhlaghi, J.

doi:10.1016/s1754-3207(11)70280-2

Cited by 25 publications

(24 citation statements)

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“…Recent therapeutic strategies developed to prevent the occurrence of heart failure after myocardial infarction (MI) [9] relies mainly on the administration of pro-angiogenic agents and stem cell therapy [10]; however, some of these data show the lack of effectiveness of these active bio-molecules because of their short radioactive half-life and reduced stability [11]. Therefore, there is an urgent need to develop a more efficient heart-targeted nanoparticle (NP) drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in magnetoliposome for heart drug delivery

Namdari

Cheraghi

Negahdari

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Magnetic nanoparticles (NPs) also have been subject of interest to the therapeutic and imaging field because of their unique magnetic properties. Magnetoliposomes (MLs) are made up of a combination of liposomes and magnetic NPs, and they have been proven to be a potential biomaterial to fields like magnetic-targeted drug delivery, MRI, etc. The efficiency of a drug delivery system to the heart determines the treatment strategy for most of the heart diseases. In this review article, we summarize the recent development and updates in the application of MLs as a drug delivery system for heart/cardiac diseases.

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Section: Introductionmentioning

confidence: 99%

Recent advances in magnetoliposome for heart drug delivery

Namdari

Cheraghi

Negahdari

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…This information, therefore, supports a predominant role played by TMD as a direct inhibitor of immediate or reflex nociception (phase 1), while IBU would behave as a strong agonist working on the late inflammatory pain response. This response for TMD has been studied by numerous clinical trials focused on its local anesthetic effect, with very promising results [Pang et al., ; Tsai et al., ; Altunkaya et al., ; Pozos et al., ; Vahabi et al., ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the mechanism of action is unclear [Yalcin and Aksu, ], this drug is a weak μ‐opioid receptor (MOR) agonist and a monoamine (norepinephrine and serotonin) uptake inhibitor [Grond and Sablotzki, ]. However, the majority of information supporting both mechanisms is based on systemic administration models, thus involving central pharmacological sites [Vahabi et al., ]. Ibuprofen (IBU) is a nonsteroidal anti‐inflammatory drug (NSAID), acting via cyclooxygenase (COX) inhibition centrally and peripherally.…”

Section: Introductionmentioning

confidence: 99%

Peripheral Synergism between Tramadol and Ibuprofen in the Formalin Test

Chavarría‐Bolaños

Pèrez‐Urizar

Grandfils

et al. 2014

Drug Development Research

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Preclinical Research Analgesics with different mechanisms of action can be combined in order to obtain pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical dual analgesic such as tramadol (TMD) and a nonsteroidal anti-inflammatory drug such as ibuprofen (IBU) are good candidates to be evaluated when combined and applied peripherally. The present study was conducted to evaluate possible local synergism between TMD and IBU when combined peripherally using the formalin test in rats. The effects of the individual analgesics and their combinations were evaluated simultaneously using a 5% formalin dilution. Dose-effect curves were determined for TMD (50-400 μg/paw) and IBU (1-100 μg/paw). Experimental effective doses were evaluated and isobolographic analyses were constructed to evaluate TMD-IBU combination synergism. Both drugs produced a dose-dependent analgesic effect when applied separately. Isobolographic analysis showed synergism during phase 1 (0-10 min) and phase 2 (15-60 min) when compared with theoretical doses (P < 0.05), with interaction indexes of 0.06 and 0.09, respectively. The present information supports the peripheral analgesic effect of TMD and IBU, especially when combined at appropriate doses.

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“…17 Penelitian tentang perbandingan kekuatan tramadol dengan lidokain dalam mengurangi nyeri pada saraf tepi didapatkan bahwa tidak terdapat perbedaan bermakna (p>0,05). 18 Uji statistik chi-kuadrat menyatakan hasil tidak terdapat perbedaan bermakna (p>0,05) antara tramadol 50 mg i.v. dengan lidokain 2% 40 mg i.v.…”

Section: Pembahasanunclassified

Perbandingan Tramadol dengan Lidokain untuk Mengurangi Derajat Nyeri Penyuntikan Propofol

Endarto¹,

Sitanggang²,

Rismawan³

2019

jap

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Propofol adalah obat anestesi intravena yang sering digunakan untuk tidakan medis karena memiliki onset dan durasi cepat. Nyeri saat penyuntikan propofol merupakan permasalahan yang sering dikeluhkan pasien dan berbagai metode telah dilakukan untuk mengurangi derajat nyeri penyuntikan propofol, namun masih didapatkan nyeri. Lidokain menjadi standar emas untuk mengurangi derajat nyeri penyuntikan propofol, tetapi masih memiliki efek samping seperti penekanan fungsi jantung sehingga dipilih tramadol yang tidak menekan fungsi jantung dan dapat menurunkan kebutuhan obat antinyeri selama maupun setelah operasi. Penelitian ini bertujuan membandingkan pemberian tramadol dengan lidokain untuk mengurangi derajat nyeri penyuntikan propofol. Metode penelitian menggunakan uji klinis acak buta tunggal terhadap 60 pasien yang menjalani operasi elektif. Pasien dibagi menjadi 2 kelompok, yaitu perlakuan tramadol (kelompok T) dan perlakuan lidokain (kelompok L) disertai pembendungan vena permukaan menggunakan tourniquet, kemudian diberikan tramadol atau lidokain. Setelah 1 menit tourniquet dilepaskan dan diikuti dengan penyuntikan ¼ dosis total propofol untuk induksi selama 5 detik, lalu dilakukan penilaian derajat nyeri menggunakan verbal rating score. Hasil penelitian menunjukkan penurunan derajat nyeri penyuntikan propofol pada kedua kelompok dan tidak terdapat perbedaan bermakna (p>0,05), namun melalui uji statistik dengan tingkat kepercayaan sebesar 95% menyatakan tramadol memiliki risiko relatif kemungkinan terjadi nyeri ringan lebih kecil dibanding dengan lidokain menurunkan derajat nyeri penyuntikan propofol. Simpulan, Tramadol memiliki kekuatan yang sama dengan lidokain dalam menurunkan derajat nyeri penyuntikan propofol.Comparison between Tramadol and Lidocaine in Reducing Pain Triggered by Propofol InjectionPropofol is a commonly used intravenous anesthetics in medical procedure. Pain during propofol injection is a commonly reported adverse effect of this injection. Various methods have been proposed to reduce pain but often fail. Lidocaine is the gold standard for reducing pain during injection of propofol but has a suppressive effect on the heart. Tramadol does not have a suppressive effect and reduce the need for anti-pain medication during and after surgery thereforeTramadol is chosen for this purpose. This study aimed to compare the administration of tramadol and lidocaine to reduce the level of pain during propofol injection. This was a single blind randomized clinical trial on 60 patients underwent elective surgery. Patients were divided into 2 groups: the first group received tramadol (group T) and the second group received lidocaine (group L). Tourniquet was used on each patient before injection of tramadol or lidocaine was given and it was removed after 1 minute. Pain severity was assessed 5 seconds after propofol injection using the verbal rating score. This study discovered that pain during propofol injection was reduced with the use of tramadol and lidocaine without significant difference between the two (p>0.05). However, tramadol has a lower probability of mild pain than lidocaine with interval confidence 95%. In conclusion, tramadol has the same potential as lidocaine in reducing the level of pain related to propofol injection.

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T606 Comparison of Local Anesthetic Effects of Tramadol and Lidocaine Used Subcutaneously in Minor Surgeries With Local Anesthesia

Cited by 25 publications

References 0 publications

Recent advances in magnetoliposome for heart drug delivery

Recent advances in magnetoliposome for heart drug delivery

Peripheral Synergism between Tramadol and Ibuprofen in the Formalin Test

Perbandingan Tramadol dengan Lidokain untuk Mengurangi Derajat Nyeri Penyuntikan Propofol

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