2022
DOI: 10.1155/2022/1217918
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TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway

Abstract: Background. Transforming growth factor β1-activated kinase 1 binding protein 2 (TAB2) mediates a variety of biological processes through activated nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB) signaling pathways. TAB2 has been reported to be upregulated in a variety of tumors. However, little is known about its potential role in oral squamous cell carcinoma (OSCC). Material and Methods. Patients’ clinicopathological and transcription data were obtained from The Cancer Genome Atlas (TCGA) da… Show more

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Cited by 5 publications
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“…Activated B cells, a type of signal transduction mediator, convert Transforming growth factor beta1-Activated kinase 1-Binding protein 2 (TAB2) into multiple biological processes. Of note, a prior study unraveled the potential pathogenic role of TAB2 in OSCC through activated B cells [11] . Furthermore, there is a notable association between the quantity of CD4 + T helper cells (Th1) and the concentration of CD8 + T cells within the TME [12] .…”
Section: Resultsmentioning
confidence: 99%
“…Activated B cells, a type of signal transduction mediator, convert Transforming growth factor beta1-Activated kinase 1-Binding protein 2 (TAB2) into multiple biological processes. Of note, a prior study unraveled the potential pathogenic role of TAB2 in OSCC through activated B cells [11] . Furthermore, there is a notable association between the quantity of CD4 + T helper cells (Th1) and the concentration of CD8 + T cells within the TME [12] .…”
Section: Resultsmentioning
confidence: 99%