Tabac et fertilité chez la femme et l'homme

Sepaniak, Sandrine; Forges, Thierry; Monnier‐Barbarino, Patricia

doi:10.1016/j.gyobfe.2006.06.018

Cited by 13 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was accordance with that reported by Sepaniak et al who found the spermatozoa of smokers have a significantly higher DNA fragmentation than those of non-smokers. They also found some trend toward lower sperm motility in spermatozoa with DNA fragmentation > 35 % [22] .…”

Section: Discussionmentioning

confidence: 90%

Sperm DNA Damage In Smokers

et al. 2017

View full text Add to dashboard Cite

Background: Cigarette smoking is the largest preventable risk factor for morbidity and mortality in developed countries. It negatively affects male reproduction and fertility. Sperm DNA damage is one of the possible incriminating causes of diminishing fertility potential in smokers as there was a strong evidence of a link between oxidative DNA damage and the chronic complications of smoking. This has potential implications for their reproductive health, particularly given the association between sperm DNA damage and infertility, miscarriage in pregnancies fathered by these men, childhood disease. Aim: The aim of this work was to assess the integrity of sperm DNA in infertile smoker patients. Patients and methods: Sperm DNA damage was assessed using flow-cytometry in 30 infertile smoker male patients and 1 5-age matched healthy non-smoker fertile males as a control group. Results: There was an increase in the DNA fragmentation index (DFI) in smokers when compared with controls. There was a significant positive correlation between DFI with the age of patients, smoking index and duration of smoking. A significant positive correlation between DFI and sperm morphology (abnormal forms %) was found. On the other hand, there was a negative correlation between the DFI and other seminal parameters including semen volume (ml), sperm count (millions/ml) and sperm motility (active progressive%, first hour). Conclusion: This study suggested that smoking can cause sperm DNA damage that affects the quality of the ejaculated spermatozoa and their fertility potential and pregnancy outcome.

show abstract