Introduction: Smoking is the main cause of disease and death worldwide, being a frequent comorbidity in hospitalized patients, with longer stays and worse results. At Hospital de Clínicas, there are no studies evaluating the prevalence of smoking in hospitalized users since 2005. Objective: to assess the prevalence of smokers and their characteristics in patients admitted to the moderate care room of a University Hospital. Methods: Observational, analytical, cross-sectional study. Results: 100 patients were included, 38% were smokers, 27% ex-smokers and 35% had no history of smoking. The mean age was 48.65 years among the smokers; 63.11 in former smokers; 58.68 in non-smokers. 44.73% of the smokers reported abstinence and intended to maintain abstinence. The mean hospitalization of the group of smokers was 31.07 days, while among non-smokers it was 20.11 (p = 0.1337). 14% of the study population died during hospitalization. Of this group, 14.28% were not smokers, 28.57% were ex-smokers and 57.14% were smokers (p = 0.0569). The mean age of death in smokers was 49.37 years, in ex-smokers it was 70.75 years and 76 years in non-smokers. Conclusions and Implications: high prevalence of smoking in hospitalized patients, with longer