Tabebuia aurea decreases hyperalgesia and neuronal injury induced by snake venom

Malange, Kauê Franco; Santos, Gilson Gonçalves dos; Kato, Natália Naomi; Toffoli-Kadri, Mônica Cristina; Carollo, Carlos Alexandre; Silva, Denise Brentan; Portugal, Luciane Candeloro; Alves, Flávio Macêdo; Rita, Paula Helena Santa; Parada, Carlos Amílcar; Rondon, Eric Schmidt

doi:10.1016/j.jep.2018.12.037

Cited by 18 publications

(10 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…& Hook. F. ex S. Moore (Cao et al 2019;Malange et al 2019). This compound has already been identified in some species from other genera, including Ailanthus integrifolia Lamk, Buddleja alternifolia Maxim, Kigelia africana (Lam.)…”

Section: Introductionmentioning

confidence: 80%

“…Extracts from Tabebuia species have shown anti-inflammatory, antioxidant, anti-hemorrhagic, anti-diabetic, anti-cancer, anti-obesity, antibacterial and antihyperalgesic activities (Ospina et al 2013;Huang et al 2019;Malange et al 2019). The Tabebuia genus has a storage capacity for iridoid glycosides, which has been described as important chemotaxonomy markers (Santos et al 2017).…”

Section: Resultsmentioning

confidence: 99%

“…In experimental mice, its hydroethanolic extract decreases the inflammatory, haemorrhagic and myotoxic activities induced by the venom of Bothrops neuwiedi Wagler, 1824 (Reis et al 2014). Additionally, this extract reduces the paw edema induced by the venom of Bothrops moojeni Hoge, 1966 (Carollo et al 2015), as well as the hyperalgesia and neuronal injury induced by Bothrops mattogrossensis Amaral, 1925 venom (Malange et al 2019). Although T. aurea extracts are effective in reducing inflammation caused by snake venom, specioside, present in these extracts, had not yet been tested as anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacological properties of specioside from the stem bark of Tabebuia aurea

Nocchi

Kato

Almeida

et al. 2020

Rev. Bras. Farmacogn.

Self Cite

View full text Add to dashboard Cite

Iridoids are secondary metabolites with several biological activities. They are often found in species of the genus Tabebuia Gomes ex A.P. de Candolle. Tabebuia aurea (Silva Manso) Benth. & Hook. F. ex S. Moore, Bignoniaceae, is used to treat snake bites in traditional medicine. This study aimed to isolate the specioside -an the iridoid glycoside -from T. aurea, as well as investigate its potential biological properties, including anti-inflammatory, antibacterial, antibiofilm, cytotoxic, anti-Trichomonas vaginalis and antitrypanosomal activities. Specioside inhibited leucocyte recruitment into the peritoneal cavity in mice injected with carrageenan, data that demonstrated its anti-inflammatory potential. However, the additional evaluated biological properties were negligible.

show abstract

Section: Introductionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological properties of specioside from the stem bark of Tabebuia aurea

Nocchi

Kato

Almeida

et al. 2020

Rev. Bras. Farmacogn.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Estudos comprovaram que suas cascas são um poderoso agente antiinflamatório, analgésico e promovem redução dos danos causados por veneno de cobra em estudos com animais. A principal substância encontrada em grande quantidade em suas cascas do caule é o iridóide especiosídeo (Figura 3), podendo este ser um potencial alvo para desenvolvimento de fármacos e produtos, já que sua elevada produção e acúmulo na espécie facilita sua obtenção [17,18].…”

Section: A Química Contida Na Biodiversidade Do Pantanalunclassified

Bioma Pantanal: Da complexidade do ecossistema à conservação, restauração e bioeconomia

Silva,

Garcia,

Santos

et al. 2023

C&C

View full text Add to dashboard Cite

O Pantanal é um bioma amplamente conhecido por ser a maior planície inundável do mundo, mais do que isso, é um mosaico contendo áreas inundáveis e não inundáveis, floresta decidual, savana (cerrado), florestas ripárias, pastagens, áreas temporárias, áreas permanentemente aquáticas e com formações monodominantes características. É um reservatório de biodiversidade com organismos adaptados aos ciclos de seca, cheia e fogo, requerendo atenção especial para sua conservação e restauração, ainda mais com os desmatamentos e incêndios catastróficos que recentemente ocorreram. Essa região também possui populações indígenas e tradicionais, que detêm inclusive conhecimentos ancestrais sobre a biodiversidade da região e precisam ser incluídas nos planejamentos para a conservação e restauração desse bioma.

show abstract

“…Latino and Haitian populations were also reported to use this plant for the treatment of infectious disease [ 32 ]. Brazilian people have traditionally used this plant for anti-inflammatory, analgesic, and antiophidic purposes against snake venom [ 33 ]. Traditional healers in Brazil prescribed T. impetiginosa for cancer and tumor prevention or treatment; 69.05% for the treatment of tumors and cancer in general and 30.95% for specific tumors or cancers [ 34 ].…”

Section: Traditional Usesmentioning

confidence: 99%

Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

et al. 2020

View full text Add to dashboard Cite

Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

show abstract

Tabebuia aurea decreases hyperalgesia and neuronal injury induced by snake venom

Cited by 18 publications

References 57 publications

Pharmacological properties of specioside from the stem bark of Tabebuia aurea

Pharmacological properties of specioside from the stem bark of Tabebuia aurea

Bioma Pantanal: Da complexidade do ecossistema à conservação, restauração e bioeconomia

Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

Contact Info

Product

Resources

About