TABLE OF ABNORMAL HUMAN GLOBINS *: With References

Hunt, Leigh; Dayhoff, M. O.

doi:10.1111/j.1749-6632.1974.tb21927.x

Cited by 10 publications

(4 citation statements)

References 205 publications

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“…While absent from vertebrate and some invertebrate globin genes, a centrally located intron has been reported in several plant, one protozoan, and a number of invertebrate globin genes (Hunt et al 1978;Jensen et al 1981;Dixon et al 1992;Moens et al 1992;Sherman et al 1992;Sulston et al 1992;Yamauchi et al 1992). None are located at the position predicted by G6: The codon for E11, the 1 lth residue of the E helix.…”

Section: Discordant Locations Of Globin Gene Central Intronsmentioning

confidence: 99%

Intron-containing globin genes in the insect Chironomus thummi

1994

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All previously reported chironomid globin genes are intronless, suggesting that the ancestral chironomid globin gene was also intronless. In this study, the coding regions of the closely linked Chironomus thummi globin (Gbs) II beta and IX genes are shown to be interrupted by noncoding DNA bounded by a 5'-GT and a 3'-AG. Both genes have appropriately placed transcription and translation signals. Polymerase chain reactions on genomic DNA with oligonucleotides flanking and within the putative Gb II beta intron generated products the size predicted for a gene with a 64-nucleotide intron, and sequencing of a cloned PCR fragment also revealed the intron. A partial-length Gb II beta cDNA sequence exactly matches that of the Gb II beta coding regions. We conclude that the intron-containing chironomid globin genes are functional. Regions of the Gb II beta and IX genes spanning the introns are more similar (86%) than the exons themselves (72% similarity), possibly due to partial gene correction. Surprisingly, Gb II beta and IX gene homologues in C. tentans are intronless. If the common ancestor of chironomid globin genes was not intronless, introns were lost in at least three C. thummi globin-gene lineages, and more recently by Gb II beta and Gb IX genes in C. tentans. If, as previously believed, the ancestral chironomid globin gene was intronless, the ancestral chironomid globin gene was intronless, then an intron was recently acquired in only one C. thummi globin sublineage. These alternatives are discussed.

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Section: Discordant Locations Of Globin Gene Central Intronsmentioning

confidence: 99%

Intron-containing globin genes in the insect Chironomus thummi

1994

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“…More than 200 mutant human hemoglobins have been described (1). These have arisen as the result of amino During the early part of the work, Dr. R. Winslow was supported by Training Grant AM05260 from the National Institute of Arthritis, Metabolism and Digestive Diseases, Bethesda, Md., and research grant HL-02799-17 from the National Heart and Lung Institute.…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin McKees Rocks (alpha2beta2145Tyr leads to Term). A human "nonsense" mutation leading to a shortened beta-chain.

Winslow¹,

Swenberg²,

Groß³

et al. 1976

J. Clin. Invest.

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“…For the present analysis the human beta hemoglobin chain was used together with the 152 variants listed in either Lehmann and Kynoch (1976) or Hunt and Dayhoff (1974), plus the recently discovered hemoglobin Strasbourg (Garel et al, 1976). The result is shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The restriction of codon ambiguity on the basis of known variants

Fitch

1977

J Mol Evol

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The genetic code may be used to formulate the nucleotide sequence of a messenger RNA from the known amino acid sequence of a protein. Unfortunately, the degeneracy of the code means that there will be ambiguity in the nucleotide assignments in a third or more of the positions. A simple procedure is given that utilizes the information of known genetic variants to reduce that ambiguity. Problems associated with silent polymorphism are treated. The human alpha and beta hemoglobins are used to exemplify the technique. A total of 68 nucleotides in the two sequences are thereby made less ambiguous. One reduction leads to a nucleotide inconsistent with the result of the recently published beta hemoglobin sequence.

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TABLE OF ABNORMAL HUMAN GLOBINS *: With References

Cited by 10 publications

References 205 publications

Intron-containing globin genes in the insect Chironomus thummi

Intron-containing globin genes in the insect Chironomus thummi

Hemoglobin McKees Rocks (alpha2beta2145Tyr leads to Term). A human "nonsense" mutation leading to a shortened beta-chain.

The restriction of codon ambiguity on the basis of known variants

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