Tablet capping predictions of model materials using multivariate approach

Basim, Pratap; Haware, Rahul V.; Dave, Rutesh H.

doi:10.1016/j.ijpharm.2019.118548

Cited by 15 publications

(16 citation statements)

References 21 publications

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“…It was obvious that formulations 1, 2, and 3 (low amount of added water) produced tablets with a higher capping tendency. This could be attributed to improper wetting of powder particles and elevation of the percent fines [ 41 ]. This finding clearly suggested the inadequacy of these formulations for preparing of tablets with acceptable attributes.…”

Section: Resultsmentioning

confidence: 99%

Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

et al. 2020

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Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process. There are no reports in the literature regarding the development of ODT based on MADG technology. The feasibility of developing metformin ODT was assessed utilizing a 32 full factorial design to elucidate the influence of water amount (X1) and the amount of pregelatinized starch (PGS; X2) as independent variables on key granules and tablets’ characteristics. The prepared granules and tablets were characterized for granule size, bulk density, flow properties, tablets’ weight variation, breaking force, friability, capping tendency, in vitro and in vivo disintegration, and drug release. Regression analysis showed that X1 and X2 had a significant (p ≤ 0.05) impact on key granules and tablets’ properties with a predominant effect of the water amount. Otherwise, the amount of PGS had a pronounced effect on tablet disintegration. Optimized ODT was found to show better mechanical strength, low friability, and short disintegration time in the oral cavity. Finally, this technique is expected to provide better ODT for many kinds of high-dose drugs that can improve the quality of life of patients.

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Section: Resultsmentioning

confidence: 99%

Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

et al. 2020

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“…The cationic chitosan combines with the anionic alginate forming a polyelectrolyte complex showing improved mechanical properties and cell proliferation. The concentration of alginate in the composite defines the pore size of the alginate-chitosan scaffold [101].…”

Section: Biopolymer-biopolymer Functionalizationmentioning

confidence: 99%

“…Polysaccharide with protein composite: Alginate has been chemically modified (by methacrylate) to obtain control over the degradation rate, mechanical and swelling properties. It is further combined with the collagen to develop hydrogels demonstrating higher mechanical moduli, improved cell proliferation, osteogenic differentiation, decreased swelling ratios on comparison with pure methacrylated alginate hydrogel [101][102][103].…”

Section: Biopolymer-biopolymer Functionalizationmentioning

confidence: 99%

Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

2021

Archives of Gastroenterology Research

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Biopolymers are the polymers extracted from living organisms either from renewable plant or animal sources are gaining importance due to their better biodegradability, biocompatibility, less/no immunogenicity, less/no toxicity, and availability. Polysaccharides (e.g., chitosan, cellulose), polypeptides (e.g., collagen, silk), and polynucleotides are the important class of biopolymers that are finding multidisciplinary applications in biomedical fields. At the other end, lipid-based systems are having their special concern in drug delivery due to their advantages over other excipient systems. In this present review, various classes of biopolymers and their fusion with conventional lipids for amalgam entity using advanced techniques for futuristic biomedicine applications are outlined. The comprehensive focuses on upbringing the importance and types of functionalization techniques explored for designing deliverable for various unmet clinical needs. Along with recent trends, the scrutiny even addresses the future perspective of these hybrid systems impacting in addressing the pharceutical, formulational and clinical challenges in treating gasteroentric diseases.

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“…Tablet Density = Tablet mass (g)/Tablet volume (cm 3 )...Eq (4) Tablet porosity (ε) = 1 -Tablet density (g/cm 3 ) / Powder true density (g/cm 3 )…Eq ( 5)…”

Section: Tablets Physicalmentioning

confidence: 99%

“…Also, the least pressure that is needed to be applied to a powder to form an intact tablet can be known by studying compressibility and compactability of powders. Unfortunately, till this day, tablet manufacturing science lacks a universal compression equation that can enable understanding and predicting compression of powders into tablets 3 . The reason behind this is that the process of compressing powders into tablets depends on many formulation and manufacturing factors 4 .…”

mentioning

confidence: 99%

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2021

IJPSR

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The present work evaluates the impact of alterable manufacturing and formulation factors on the physicomechanical properties of Acetaminophen (APAP); a poorly compressible Active Pharmaceutical Ingredient (API). By varying the amount of APAP and particle size of Microcrystalline Cellulose (MCC), six different formulations were prepared. These formulations were compressed into tablets at different compression pressures and speeds. The porosity of the tablets was evaluated through "outof-die" Heckel analysis. Furthermore, the qualitative and quantitative relationships of (i) Percentage of APAP, (ii) Compression pressures, (iii) Compression speeds, and (iv) Particle size of MCC with tablet porosity were evaluated by principle component analysis (PCA) and principle component regression (PCR). Heckel analysis revealed that increasing the ratio of APAP to MCC in the formulation adds its compressibility when the MCC particle size is similar to that of APAP. While, using large MCC particle size increases the compressibility due to fragmentation of particles, using MCC of small particle size increases the compressibility to a higher extend. The PCA indicated that the percentage of APAP, compression pressure and particle size of MCC are all correlated negatively to tablet porosity. Furthermore, the PCR quantified these correlations to show that tablet porosity was predominantly dependent on compression pressure followed by MCC particle size, APAP percentage, and compression speed in descending order. This work provides an insight into the collective impact of manufacturing and formulation factors on the mechanical properties of tablets, which can help developing an optimized multivariate function to ensure tablet quality of poorly compressible APIs.

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Tablet capping predictions of model materials using multivariate approach

Cited by 15 publications

References 21 publications

Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

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