Tablet disintegration monitored by magnetic resonance imaging

Kwiecinski, S.; Weychert, M.; Jasiński, A.; Kulinowski, Piotr; Wawer, Iwona; Sieradzki, Edmund

doi:10.1007/bf03170520

Cited by 7 publications

(1 citation statement)

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“…Spatially resolved NMR is usually termed as MRI. Porosity [ 71 ], density distribution [ 20 , 45 , 72 ], and dissolution of the tablet [ 44 , 73 ] can be characterized by MRI imaging. Furthermore, in situ studies on the drug release and absorption in human or animal subjects can also be carried out by MRI [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

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Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.

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Section: Introductionmentioning

confidence: 99%

Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

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Pharmaceutical Technology Studied by MRI

Reid

Byard

1996

eMagRes

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This article describes the use of MRI to investigate the performance of pharmaceutical dosage forms both in vitro and in vivo. Various commonly used strategies and excipient materials available for controlling drug release are related to MRI methods that are applied to characterize their behavior in biomimetic and biological environments, and also to those circumstances under which application of MRI can be crucial in a pharmaceutical development process. Examples of MRI used in the study of rapid, controlled, and implanted drug-delivery forms are presented and discussed. These include dosage forms based on shaped, multilayer, and membrane designs, and a range of hydrophobic and hydrophilic excipients. Approaches to more detailed understanding based on measuring solvent penetration and diffusion, matrix erosion and disintegration, and correlation between dosage form behavior and drug release are summarized. A significant increase in the use of MRI for industrial dosage form design, testing, quality assurance, and troubleshooting is anticipated.

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