By harnessing the power of 21st-century, the use of cloud computing resources in higher education has emerged as a hot area for deploying innovative technologies in teaching and learning. Accordingly, the core objective of the present study is to analyze the inclination towards the utilization of cloud-based technologies among pre-service teachers in the present digital environment. Based on studies reviewed, a research model was developed with five usability factors - perceived usefulness, perceived ease of use, perceived security, frequency of usage, and behavior intention. Quantitative survey method was used to collect data among 252 pre-service teachers in Karaikudi locality. Factor Analysis, Percentage Analysis, Pearson Correlation Analysis, Multiple Linear Regression Analysis were employed for data analysis Statistical analysis of the data indicates that pre-service teachers exhibit a favorable inclination towards using cloud-based technologies with a moderate extent, which is predominantly influenced by perceived ease of use. It is evident from the present study that pedagogical approaches need to change for successful integration of technology in future classrooms and for the development of sustainable educational practices.