Tableting functionality evaluation of Prosolv Easytab in comparison to physical mixtures of its individual components

Aljaberi, Ahmad; Ardakani, Adel; Khdair, Adnan I.; Rahim, Safwan Abdel; Meqdadi, E.; Ayyash, M.; Alobaidi, Ghadah; Al-Zoubi, Nizar

doi:10.1016/s1773-2247(13)50072-4

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…It can be simply mixed with granules or DC grades of active ingredients to form an RTC mixture [108], but extra disintegrant has to be added for products containing high content of solid dispersions in order to shorten the disintegration time [109]. Aljaberi et al [110] compared the compaction and dissolution performance of Prosolv ® EASYtab with corresponding physical mixtures of MCC or SMCC with complementary excipients (colloidal silicon dioxide, sodium starch glycolate, and sodium stearyl fumarate). Prosolv ® EASYtab exhibited comparable compactability, dissolution and stability with the corresponding MCC or Prosolv ® SMCC physical mixtures.…”

Section: Silicified Microcrystalline Cellulosementioning

confidence: 99%

Spray Drying for Direct Compression of Pharmaceuticals

et al. 2021

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Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.

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Section: Silicified Microcrystalline Cellulosementioning

confidence: 99%

Spray Drying for Direct Compression of Pharmaceuticals

et al. 2021

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“…PROSOLV ® EASYtab is a multi-functional co-processed excipient that produces similar functionalities to the physical mixture from its individual components while improving process-related quality attributes and minimizing undesirable properties that may be associated with the physical mixture [11].…”

Section: Plant Materialsmentioning

confidence: 99%

Selected Excipients in Oral Solid Dosage Form With Dry Extract of Pyrola Rotundifolia L.

2019

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Objective: The aim of the present study was to select excipients in an oral solid dosage form with a dry extract of round-leaved wintergreen (Pyrola rotundifolia L.) by using asymmetric, rotatable composite plan of the second-order (uniform plan No. 17). Methods: The tablets were prepared by using a direct compression method. The most important pharmaceutical factors selected were considered in more details at developing the optimal composition and technology of the studied tablets of the round-leaved wintergreen extract. Each one was studied at five levels using asymmetric, rotatable composite plan of the second order. Results: Increasing amounts of PROSOLV® EASYtab SP and croscarmellose sodium in the powder mass, its flowability decreases, and increasing amounts of Tablettose® 80 improves flowability. Increasing the amount of Tablettose® 80 in the tablets composition leads to improved uniformity. The strength of the tablets increased with increasing amounts of Neusilin® US 2 at different combinations of levels of the other three factors. When studying the effect of the amounts of croscarmellose sodium on the disintegration of tablets, it was found that the best disintegration values were obtained in the study of croscarmellose sodium at the upper level. Conclusion: Oral solid dosage form with dry extract of round-leaved wintergreen was successfully prepared by the direct compression method. The optimal composition of tablets was determined by the regression analysis.

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“…ProsolvEASYtab SP ® made by co-processing microcrystalline cellulose (a dry binder), colloidal silicon dioxide (a glidant), sodium starch glycolate (a disintegrant), and sodium stearyl fumarate (a lubricant) at 96.5:2:1:0.5 ratios, with average particle size 140 (µm) 38 . Although Prosolv EASY tab SP® gave short DT, and WT which may be related to the presence of a disintegrant in its components, but it was observed delaying of drug release (96.26 ± 0.0078%) at 30 mint.…”

Section: Fig 2: In-vitro Dissolution Profiles Of Prepared Odts (M6 mentioning

confidence: 99%

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2019

IJPSR

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Different types of excipients were compared, in terms of their effect in (oral disintegrated tablets-ODTs) to optimize drug delivery and manufacturability. Therefore, the influence of excipients on the quality of ODTs was investigated by formulating and evaluate ODTs using an equal dose of water-soluble Baclofen (B) and poorly watersoluble Meloxicam (M) as model drugs. ODTs of both drugs were prepared using nine different co-process excipients for (B1-B9) and (M1-M9) formula (Pharmaburst ® , Ludiflash ® , F-melt ® , Prosolv HD 90 ® , Prosolv SMCC 5O ® , Prosolv ODT G2 ® , ProsolvEASYtab SP ® , ProsolvEASYtab Nutra ® , Lactose microfine), respectively by direct compression method. The prepared ODTs were evaluated for their: drug content, weight variation, thickness, disintegration time, wetting time, hardness, friability, and in-vitro dissolution. Both B-ODTs and M-ODTs showed no significant difference in the results of ODTs evaluation, by Using Design Expert 10 to select the best formulae of both drugs the best formulae were for poor water-soluble M9 (Lactose) > M3 (F-melt) > M6 (pro ODT) > M1 (Ph.brust) and for water-soluble: B4(Pro HD 90) > B3 (F-melt) > B6 (Pro ODT) > B1 (Ph.brust) F-melt ® , Prosolv ODT G2 ® , and Pharmaburst ® 500 co-processed excipients showed the best result of quality control test and performed with no significant difference between water soluble and poor water-soluble drug, made them highly recommended to be utilized in ODT formulation.

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Tableting functionality evaluation of Prosolv Easytab in comparison to physical mixtures of its individual components

Cited by 13 publications

References 7 publications

Spray Drying for Direct Compression of Pharmaceuticals

Spray Drying for Direct Compression of Pharmaceuticals

Selected Excipients in Oral Solid Dosage Form With Dry Extract of Pyrola Rotundifolia L.

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