Tabular Data of the Velocity and Absorption of High-Frequency Sound in Mammalian Tissues

Goldman, David E.; Hueter, T. F.

doi:10.1121/1.1908216

Cited by 168 publications

(33 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The range for the speed of sound in the entire temporal bone was also reported to be from 2570 to 3030 m/s by Fry and Barger (1978). Goldman and Hueter (1955) and Goss et al (1978) reported a speed of sound in skull of 3360 m/s at 0.8 MHz. Three of our skulls exhibited a speed of sound in the range found in the literature.…”

Section: Discussionmentioning

confidence: 94%

Characterization of Ultrasound Propagation Through Ex-vivo Human Temporal Bone

Ammi

Mast

Huang

et al. 2008

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Adjuvant therapies that lower the thrombolytic dose or increase its efficacy would represent a significant breakthrough in the treatment of patients with ischemic stroke (Eggers 2006;Tsivgoulis and Alexandrov 2007). The objective of this study was to perform intracranial measurements of the acoustic pressure field generated by 0.12, 1.03 and 2.00 MHz ultrasound transducers to identify optimal ultrasound parameters that would maximize penetration and minimize aberration of the beam. To achieve this goal, in vitro experiments were conducted on five human skull specimens. In a water-filled tank, two unfocused transducers (0.12 and 1.03 MHz) and one focused transducer (2.00 MHz) were consecutively placed near the right temporal bone of each skull. A hydrophone, mounted on a micropositioning system, was moved to an estimated location of the middle cerebral artery (MCA) origin and measurements of the surrounding acoustic pressure field were performed. For each measurement, the distance from the position of maximum acoustic pressure to the estimated origin of the MCA inside the skulls was quantified. The -3 dB depth of field and beam width in the skull were also investigated as a function of the three frequencies. Results show that the transducer alignment relative to the skull is a significant determinant of the detailed behavior of the acoustic field inside the skull. For optimal penetration, insonation normal to the temporal bone was needed. The shape of the 0.12-MHz intracranial beam was more distorted than those at 1.03 and 2.00 MHz due to the large aperture and beam width. However, lower ultrasound pressure reduction was observed at 0.12 MHz (22.5%). At 1.03 and 2.00 MHz two skulls had an insufficient temporal bone window and attenuated the beam severely (up to 96.6% pressure reduction). For all frequencies, constructive and destructive interference patterns were seen near the contralateral skull wall at various elevations. The 0.12-MHz ultrasound beam depth of field was affected the most when passing Corresponding Address: Christy K. Holland, Ph.D., Department of Biomedical Engineering, Colleges of Medicine and Engineering, University of Cincinnati, Medical Science Building, Rm. 6167, 231 Albert Sabin Way, Cincinnati, Ohio 45267-0586, USA, Phone: +1 (513) 558-5675, Fax: +1 (513) 558-5958, Christy.Holland@uc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript through the temporal bone and showed a decrease in size of more than 55% on average. The speed of sound in the temporal...

show abstract

Section: Discussionmentioning

confidence: 94%

Characterization of Ultrasound Propagation Through Ex-vivo Human Temporal Bone

Ammi

Mast

Huang

et al. 2008

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…The diameter of the ultrasonic beam was 2.5 mm. The data were compiled from ICRU (1998), Hueter (1952), Hill et al (2004), Goldman and Hueter (1956) and Nahirnyak et al (2006). Experimental results for the maximum temperature rise measured in tissue exposed to pulsed ultrasound (PRP = 10 ms, P p-t-p = 0.25 MPa, I SPTA = 0.4 W/cm 2 , T = 37 °C, t = 300 s) in vitro …”

Section: Discussionmentioning

confidence: 99%

“…The values for frequency-dependent absorption coefficients utilized for the numerical calculations are presented in Table 1 (ICRU report 1998; Coussios et al 2002;Hueter 1952;Hill et al 2004;Goldman and Hueter 1956).…”

Section: Theoretical Modelmentioning

confidence: 99%

Ultrasound-Induced Thermal Elevation in Clotted Blood and Cranial Bone

Nahirnyak¹,

Mast²,

Holland³

2007

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Ultrasound thermal effects have been hypothesized to contribute to ultrasound-assisted thrombolysis. To explore the thermal mechanism of ultrasound-enhanced thrombolysis with recombinant tissue plasminogen activator (rt-PA) for the treatment of ischemic stroke, a detailed investigation is needed of the heating produced in skull, brain and blood clots. A theoretical model is developed to provide an estimate for the worst-case scenario of the temperature increase in blood clots and on the surface of cranial bone exposed to 0.12-to 3.5-MHz ultrasound. Thermal elevation was also assessed experimentally in human temporal bone, human clots and porcine clots exposed to 0.12 to 3.5-MHz pulsed ultrasound in vitro with a peak-to-peak pressure of 0.25 MPa and 80% duty cycle. Blood clots exposed to 0.12-MHz pulsed ultrasound exhibited a small temperature increase (0.25° C) and bone exposed to 1.0-MHz pulsed ultrasound exhibited the highest temperature increase (1.0° C). These experimental results were compared with the predicted temperature elevations.

show abstract

“…Ekokardiyografi ile ventrikül duvarının hareketleri ve boşluğu, kalp kası büyümeleri ve kalp kapakları incelenebilmektedir. Yapılması basittir, fakat değerlendirilmesini yapabilmek için tecrübe sahibi olmak gerekir (3)(4)(5)(6)(7)(8).…”

Section: Ekokardiografinin Fiziğiunclassified

Yoğun Bakımda Ekokardiografi Kullanımı

...

2012

tybdd

View full text Add to dashboard Cite

Tabular Data of the Velocity and Absorption of High-Frequency Sound in Mammalian Tissues

Abstract: This report is a condensed presentation of currently available data on the velocity and absorption of high-frequency sound in mammalian tissues.

Cited by 168 publications

References 0 publications

Characterization of Ultrasound Propagation Through Ex-vivo Human Temporal Bone

Characterization of Ultrasound Propagation Through Ex-vivo Human Temporal Bone

Ultrasound-Induced Thermal Elevation in Clotted Blood and Cranial Bone

Yoğun Bakımda Ekokardiografi Kullanımı

Contact Info

Product

Resources

About