Tache Cerebrale Revisited

Issaivanan, Mph Magimairajan; Bishnoi, Durlabh S; Virdi, Verinderjit S.

doi:10.1046/j.1525-1470.2002.t01-3-00038.x

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2009

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“…One possible link between coma and bullae is the role of autonomic instability-the vasodilator response of the skin to a mechanical stimulus is sometimes exaggerated in states of depressed consciousness. 5,10 Eccrine sweat gland function is also under central control with sympathetic innervation. Perhaps the combination of local drug toxic effects and disordered central drive to sweat glands could contribute to patchy blister formation with sweat gland necrosis.…”

Section: Discussionmentioning

confidence: 99%

Coma Blisters in 2 Children on Anticonvulsant Medication

et al. 2009

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Blister formation and eccrine sweat gland necrosis have been recognized to occur in states of impaired consciousness and were first reported following barbiturate intoxication. Their etiology is complex and cannot simply be explained by pressure effects. Now that barbiturates are less frequently used, clinicians are likely to be less aware of the phenomenon of coma blister formation; however, newer drugs have also been associated with the occurrence of coma blisters. We describe 2 new associations of coma blisters and anticonvulsants in children. In the first child, blisters recurred on multiple occasions along with obtundation and edema. Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters.

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Section: Discussionmentioning

confidence: 99%