Tachykinin-induced nasal fluid secretion and plasma exudation in the rat: Effects of peptidase inhibition

Lindell, Erik; Svensjö, M.E; Malm, Lars; Petersson, Göran

doi:10.1016/0143-4179(95)90047-0

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…On the other hand, the inhibition of NEP or ACE by quercetin does not augment NKA-induced PE. In fact, inhibition of NEP did not augment the NKA evoked PE at all (Lindell et al, 1995). In conclusion, this report suggests that quercetin potentiates plasma protein extravasation induced by substance P in the rat urinary bladder, possibly by inhibition of the peptidase enzyme which inactivates substance P.…”

Section: Discussionmentioning

confidence: 50%

Effect of quercetin on tachykinin‐induced plasma extravasation in rat urinary bladder

Wille

Ribeiro‐do‐Valle

Simões

et al. 2001

Phytotherapy Research

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The effect of quercetin on substance P-induced plasma extravasation in rat urinary bladder and its modulation by endogenous peptidases in conscious rats was studied. Plasma protein extravasation (PE) was assayed by measurement of extravasated Evans blue dye (microg/g dry tissue). Intravenous injection of substance P (SP, 10 nmol/kg) significantly increased PE in the urinary bladder. PE evoked by SP was increased significantly by quercetin (20 mg/kg, p.o.) pretreatment in the urinary bladder (73.5 +/- 4.9 to 152.2 +/- 9.9). Pretreatment with captopril, an angiotensin-converting enzyme (ACE) inhibitor (10 nmol/kg, i.v.), or with phosphoramidon, a neutral endopeptidase (NEP) inhibitor (2.5 micromol/kg, i.v.) also potentiated the SP-induced PE in urinary bladder, 286.2 +/- 20.4 and 323.3 +/- 34.0, respectively. Quercetin did not show any effect on neurokinin-A (NKA, 10 nmol/kg, i.v.) -induced plasma extravasation. The present study demonstrates that quercetin potentiates the PE induced by substance P in the urinary bladder. These effects suggest that this flavonoid might cause inhibition of NEP and/or ACE.

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Section: Discussionmentioning

confidence: 50%

Effect of quercetin on tachykinin‐induced plasma extravasation in rat urinary bladder

Wille

Ribeiro‐do‐Valle

Simões

et al. 2001

Phytotherapy Research

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“…Filter strips of 1.0 × 25.0 mm 2 were inserted into one of the nasal cavities of all rats to absorb nasal secretions for 5 min; then, the weight of nasal secretions (mg) was measured through weight‐reduction method. The above data were collected to evaluate nasal allergic symptoms of the rats 22 …”

Section: Methodsmentioning

confidence: 99%

Effects of rosmarinic acid on the inflammatory response in allergic rhinitis rat models after PM2.5 exposure

Zhou

Huang

Han

et al. 2022

Clinical Laboratory Analysis

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Background Studies have shown the promising prospects of rosmarinic acid (RosA) for the prevention and treatment of allergic diseases. Objective The aim of this study was to investigate the effects of RosA on inflammatory reaction in rat models of allergic rhinitis (AR) after PM2.5 exposure. Methods Allergic rhinitis rat models were established by ovalbumin sensitization, and PM2.5 was applied at a concentration of 1000 μg/m3, 3 h a day for 30 consecutive days. RosA was administered via intraperitoneal injection (20 mg/kg/d) for seven consecutive days. Allergic nasal symptoms were recorded. The expressions of interleukin (IL)‐4, IL‐13, interferon (INF)‐γ, and OVA‐sIgE were determined by ELISA. Histopathological changes in nasal mucosa were observed by HE staining. mRNA expressions of T‐bet and GATA‐3 in nasal mucosa were detected by RT‐PCR. NF‐κBp65 in cell nuclei and IκBα in cytoplasm were analyzed by Western blot. Results PM2.5 exposure worsened allergic nasal symptoms in AR rats, while RosA ameliorated these symptoms. Histopathologically, AR rats exhibited disorganized nasal mucosal epithelium, cell exfoliation, eosinophilic infiltration of lamina propria, gland swelling, and submucosal vascular congestion, which were aggravated by PM2.5 exposure and alleviated by RosA. RosA decreased the expressions of IL‐4, IL‐13, and increased the level of IFN‐γ in PM2.5‐exposed AR rats. After RosA intervention, the expressions of GATA‐3 mRNA and NF‐κBp65 in PM2.5‐exposed AR rats were significantly reduced, while those of T‐bet mRNA and IκBα were markedly increased. Conclusion Rosmarinic acid may alleviate symptoms of AR rat models exposed to PM2.5 through the modulation of the NF‐κB pathway and Th1/Th2 balance.

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Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis

Zhao

Hasselt

Woo

et al. 2006

Annals of Allergy, Asthma & Immunology

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Tachykinin-induced nasal fluid secretion and plasma exudation in the rat: Effects of peptidase inhibition

Cited by 6 publications

References 21 publications

Effect of quercetin on tachykinin‐induced plasma extravasation in rat urinary bladder

Effect of quercetin on tachykinin‐induced plasma extravasation in rat urinary bladder

Effects of rosmarinic acid on the inflammatory response in allergic rhinitis rat models after PM2.5 exposure

Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis

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