Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential

Lu, Shengxin; Lin, Jiayi; Jin, Jinmei; Zhang, Lijun; Guan, Yong-Song; Chen, Hongzhuan; Wu, Ye; Zhang, Weidong; Luan, Xin

doi:10.1080/17460441.2023.2157402

Cited by 3 publications

(4 citation statements)

References 142 publications

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“…Tachystatins exhibit a broad spectrum of antimicrobial activity against Gram-negative bacteria, Grampositive bacteria, and fungi [37,38,[134][135][136]. Tachyplesins, in addition to their antimicrobial activity, exerts a cytotoxic activity toward human cancer cells, including non-small-cell lung cancer cells, by inducing apoptosis [137][138][139]. Tachyplesins enhance the chemosensitivity of cancer cells to cisplatin, reducing the active concentrations of cisplatin [138,139].…”

Section: Cheliceratamentioning

confidence: 99%

“…On the other hand, the cytotoxicity of AMPs is supposed to be used to combat transformed and virus-infected cells. For instance, the cytotoxicity of tachyplesins toward human cancer cells, including non-small-cell lung cancer and cisplatin-resistant A549/DDP cells, enhances the chemosensitivity to cisplatin and has a promising potential as an antitumor drug [137][138][139]. Carriers and drug delivery methods are being developed to target tumor and HIV-infected cells [217,218].…”

Section: Cytotoxicitymentioning

confidence: 99%

“…For example, nicomicins from the marine polychaeta Nicomache minor possessed cytotoxicity against cancer cells (HeLa) and normal adherent cells as well as toward human erythrocyte [58]. Tachyplesins have been found to be toxic toward human non-small-cell lung cancer cells and normal cells [137][138][139]. Backbone cyclized analogs of tachyplesin 1 had increased selectivity toward melanoma cells and its analog has shown an ability to enter cells with a high efficacy and a low toxicity [255].…”

Section: Alternative Functional Properties Of Amps Derived From Marin...mentioning

confidence: 99%

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Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

Guryanova,

Balandin,

Belogurova-Ovchinnikova

et al. 2023

Marine Drugs

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Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled their existence for millions of years. Their lack of acquired immunity sets marine invertebrates apart from other marine animals. Invertebrates could rely on their innate immunity, providing the first line of defense, survival, and thriving. The innate immune system of marine invertebrates includes various biologically active compounds, and specifically, antimicrobial peptides. Nowadays, there is a revive of interest in these peptides due to the urgent need to discover novel drugs against antibiotic-resistant bacterial strains, a pressing global concern in modern healthcare. Modern technologies offer extensive possibilities for the development of innovative drugs based on these compounds, which can act against bacteria, fungi, protozoa, and viruses. This review focuses on structural peculiarities, biological functions, gene expression, biosynthesis, mechanisms of antimicrobial action, regulatory activities, and prospects for the therapeutic use of antimicrobial peptides derived from marine invertebrates.

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Section: Cheliceratamentioning

confidence: 99%

Section: Cytotoxicitymentioning

confidence: 99%

Section: Alternative Functional Properties Of Amps Derived From Marin...mentioning

confidence: 99%

See 1 more Smart Citation

Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

Guryanova,

Balandin,

Belogurova-Ovchinnikova

et al. 2023

Marine Drugs

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“…This structure's presence appears crucial for its antibacterial efficacy (Xie et al 2015 ). In previous studies, scientists discovered that combining a synthetic form of tachyplesin with the integrin homing domain RGD effectively inhibited the proliferation of cancer cells, both in laboratory settings and in living organisms (Lu et al 2022 ). RGD-tachyplesin suppressed the growth of both cultivated tumor and endothelial cells that were cultured and decreased the development of colonies in TSU cancer cells.…”

Section: Introductionmentioning

confidence: 99%

pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells

Mahmoudi-Filabadi,

Doosti

2024

Amino Acids

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Breast cancer is the most common cancer among women worldwide, and marine creatures are the most abundant reservoir of anticancer medicines. Tachyplesin peptides have shown antibacterial capabilities, but their potential to inhibit cancer growth and trigger cancer cell death has not been investigated. A synthetic tachyplesin nucleotide sequence was generated and inserted into the pcDNA3.1( +) Mammalian Expression Vector. PCR analysis and enzyme digesting procedures were used to evaluate the vectors' accuracy. The transfection efficiency of MCF-7 and MCF10-A cells was 57% and 65%, respectively. The proliferation of MCF-7 cancer cells was markedly suppressed. Administration of plasmid DNA (pDNA) combined with tachyplesin to mice with tumors did not cause any discernible morbidity or mortality throughout treatment. The final body weight curves revealed a significant reduction in weight among mice treated with pDNA/tachyplesin and tachyplesin at a dose of 100 µg/ml (18.4 ± 0.24 gr, P < 0.05; 11.4 ± 0.24 gr P < 0.01) compared to the control group treated with PBS (22 ± 0.31 gr). Animals treated with pDNA/tachyplesin and tachyplesin exhibited a higher percentage of CD4 + Foxp3 + Tregs, CD8 + Foxp3 + Tregs, and CD4 + and CD8 + T cell populations expressing CTLA-4 in their lymph nodes and spleen compared to the PBS group. The groups that received pDNA/tachyplesin exhibited a substantial upregulation in the expression levels of caspase-3, caspase-8, BAX, PI3K, STAT3, and JAK genes. The results offer new possibilities for treating cancer by targeting malignancies using pDNA/tachyplesin and activating the mTOR and NFκB signaling pathways.

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Advancements in therapeutic peptides: Shaping the future of cancer treatment

Chen,

Zhao,

Laster

et al. 2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential

Cited by 3 publications

References 142 publications

Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells

Advancements in therapeutic peptides: Shaping the future of cancer treatment

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