Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation

Badawi, Noha M.; Yehia, Rania; Lamie, Caroline; Abdelrahman, Khaled A.; Attia, Dalia; Helal, Doaa A.

doi:10.1016/j.ijpx.2023.100185

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…The maximum concentration of PEG associated with a lower surfactant concentration contributes to the expansion of the interfacial area, affecting the system stability [ 93 ]. Moreover, Badawi N.M. et al reported that in some cases, the surfactant molecules can increase droplet size by forming micellar aggregates that may hinder their normal deposition at the oil/water interface [ 94 ]. On the other hand, the microemulsions prepared with oleic acid 10%, but also the ME 10 containing oleic acid 8.75% have a different structure compared to those containing a lower oil concentration.…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery.

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Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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Resolving acne with optimized adapalene microspongeal gel, in vivo and clinical evaluations

Yehia,

Teaima,

Ragaie

et al. 2024

Sci Rep

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In our pursuit of enhancing acne treatment while minimizing side effects, we developed tailored Adapalene microsponges (MS) optimized using a Box–Behnken design 33. The independent variables, Eudragit RS100 percentage in the polymer mixture, organic phase volume, and drug to polymer percentage, were explored. The optimized formulation exhibited remarkable characteristics, with a 98.3% ± 1.6 production yield, 97.3% ± 1.64 entrapment efficiency, and a particle size of 31.8 ± 1.1 µm. Notably, it achieved a 24 h cumulative drug release of 75.1% ± 1.4. To delve deeper into its efficacy, we evaluated the optimized microspongeal-gel in vitro, in vivo, and clinically. It demonstrated impressive retention in the pilosebaceous unit, a target for acne treatment. Comparative studies between our optimized Adapalene microspongeal gel and marketed Adapalene revealed superior performance. In vivo studies on Propionibacterium acnes-infected mice ears showed a remarkable 97% reduction in ear thickness, accompanied by a significant decrease in inflammatory signs and NF-κB levels, as confirmed by histopathological and histochemical examination. Moreover, in preliminary clinical evaluation, it demonstrated outstanding effectiveness in reducing comedonal lesions while causing fewer irritations. This not only indicates its potential for clinical application but also underscores its ability to enhance patient satisfaction, paving the way for future commercialization.

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Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies

Yehia,

Lamie,

Attia

2024

Pharmaceutical Development and Technology

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Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation

Cited by 3 publications

References 54 publications

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Resolving acne with optimized adapalene microspongeal gel, in vivo and clinical evaluations

Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies

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